Publications by authors named "Milosz Pinkiewicz"
The blood-brain barrier (BBB) poses a significant challenge to drug delivery for brain tumors, with most chemotherapeutics having limited permeability into non-malignant brain tissue and only restricted access to primary and metastatic brain cancers. Consequently, due to the drug's inability to effectively penetrate the BBB, outcomes following brain chemotherapy continue to be suboptimal. Several methods to open the BBB and obtain higher drug concentrations in tumors have been proposed, with the selection of the optimal method depending on the size of the targeted tumor volume, the chosen therapeutic agent, and individual patient characteristics.
View Article and Find Full Text PDFThe paradigm is gradually shifting, with radiosurgery and endovascular embolization being increasingly chosen over surgical resection in the selected cases of brain arteriovenous malformations. Routinely used X-ray monitoring of liquid embolic infusion has very good spatial and temporal resolution but is not without significant drawbacks regarding poor visualization of the complex AVM angioarchitecture, especially after many embolizations in the past and therefore limiting the technical ability of the embocure-total occlusion of the feeding arteries, nidus, and draining veins. The purpose of this study was to evaluate the use of real-time MRI guidance in endovascular embolization with Onyx (instead of X-ray) in a single swine rete mirabile (RM) AVM model in order to provide the scaffolding for the real-time MRI guidance method.
View Article and Find Full Text PDFAs a significant cause of intracerebral hemorrhages, seizures, and neurological decline, brain arteriovenous malformations (bAVMs) are a rare group of complex vascular lesions with devastating implications for patients' quality of life. Although the concerted effort of the scientific community has improved our understanding of bAVM biology, the exact mechanism continues to be elucidated. Furthermore, to this day, due to the high heterogeneity of bAVMs as well as the lack of objective data brought by the lack of evaluative and comparative studies, there is no clear consensus on the treatment of this life-threatening and dynamic disease.
View Article and Find Full Text PDFArticle Synopsis
- Human papillomavirus (HPV) causes various head and neck cancers, particularly affecting younger, nonsmoking individuals with extensive sexual history and higher socioeconomic status.
- This review highlights the latest findings on HPV-induced head and neck cancers, aiming to equip medical professionals with crucial information on its epidemiology, prevention, diagnosis, and treatment.
- To tackle the rise of HPV-induced head and neck cancers, improving vaccination access and addressing vaccine safety concerns is essential, while precision medicine and advanced surgical techniques like transoral robotic surgery may enhance patient management and outcomes.
Article Synopsis
- * The authors analyzed 159 English articles from various databases to gather the most relevant information about the effectiveness and safety of this treatment method.
- * Although intra-arterial delivery shows promise by achieving higher drug concentrations with reduced side effects, the lack of phase III trials means benefits can't be conclusively established; thus, a multimodal treatment approach is recommended for better outcomes.
Article Synopsis
- The purpose of the study is to provide a comprehensive overview of reconstructive techniques, grading scales, and treatments related to facial paralysis, while identifying knowledge gaps and proposing a research framework.
- The research analyzed a substantial number of articles from various databases, ultimately narrowing down to 119 papers after rigorous screening based on specific criteria.
- The study concludes that thorough clinical examinations, including imaging and electromyography, are vital for diagnosing facial palsy, and emphasizes the need for consistent guidelines on facial nerve grading scales and follow-up evaluations.
A Systematic Review of Cancer of Unknown Primary in the Head and Neck Region.
Cancer Manag Res
September 2021
Article Synopsis
- * It highlights the importance of understanding the unique biology and pathophysiology of CUP, particularly with the rise in HPV-related cases, which could lead to improved targeted therapies.
- * The conclusion emphasizes the need for better diagnostic protocols and treatment guidelines, as current methods are often time-consuming with no clear consensus on the most effective treatment combinations.