Publications by authors named "Milner M Kumar"
Article Synopsis
- - The study emphasizes the importance of detecting drug resistance mutations (DRMs) in small viral populations, which is crucial for clinical treatment of HIV-1.
- - A new analysis tool called MiDRM was developed to quantify DRMs by sequencing the gag-vpu region from plasma samples, overcoming the limitations of current diagnostic labs lacking advanced computational resources.
- - Validation of MiDRM showed it can reliably detect minor mutations in HIV-1 populations (under 20%), offering a more efficient method for large-scale monitoring of drug resistance compared to existing tools like PASeq.
Background: Apophysomyces species are prevalent in tropical countries and A. variabilis is the second most frequent agent causing mucormycosis in India. Among Apophysomyces species, A.
View Article and Find Full Text PDFAnalysing the HIV-1 near full-length genome (HIV-NFLG) facilitates new understanding into the diversity of virus population dynamics at individual or population level. In this study we developed a simple but high-throughput next generation sequencing (NGS) protocol for HIV-NFLG using clinical specimens and validated the method against an external quality control (EQC) panel. Clinical specimens (n=105) were obtained from three cohorts from two highly conserved HIV-1C epidemics (India and Ethiopia) and one diverse epidemic (Sweden).
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