Small-Colony Variants from Airways of Adult Cystic Fibrosis Patients as Precursors of Adaptive Antibiotic-Resistant Mutations.

Prototypic and their small-colony variants (SCVs) are predominant in cystic fibrosis (CF), but the interdependence of these phenotypes is poorly understood. We characterized isolates from adult CF patients over several years. Of 18 -positive patients (58%), 13 (72%) were positive for SCVs.

Effective Treatment of Intramammary Infection in a Murine Model Using the Bacteriophage Cocktail StaphLyse™.

causes intramammary infections (IMIs), which are refractory to antibiotic treatment and frequently result in chronic mastitis. IMIs are the leading cause of conventional antibiotic use in dairy farms. Phage therapy represents an alternative to antibiotics to help better manage mastitis in cows, reducing the global spread of resistance.

Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of .

Tomatidine (TO), a steroid alkaloid, exerts a strong bactericidal activity on the infection-persistent phenotype of , the small-colony variant (SCV), with a minimal inhibitory concentration (MIC) of 0.06 μg/ml. Also, the combination of TO to an aminoglycoside (AMG) shows a strong synergistic effect against prototypical (WT) (MIC 0.

Despite Antagonism , Enhances Colonization in a Murine Lung Infection Model.

and are prevalent lung pathogens in cystic fibrosis (CF). Whereas co-infection worsens the clinical outcome, prototypical strains are usually antagonistic . We sought to resolve the discrepancy between these and observations.

Partial prediction of the duration and the clinical status of Staphylococcus aureus bovine intramammary infections based on the phenotypic and genotypic analysis of isolates.

Staphylococcus aureus is a bacterial pathogen causing bovine intramammary infections (IMIs) often leading to chronic clinical or subclinical mastitis. Predicting the outcome of S. aureus IMIs (duration and clinical vs subclinical) based on the characterization of isolates would help to make better case management decisions.

A reusable training circuit for cardiopulmonary bypass.

At the turn of the millennium, perfusion teaching programs are faced with significant difficulties. The number of students in pediatric perfusion training has increased, and more importantly, the number of pediatric open-heart procedures has decreased because of a variety of reasons. Hence, they could barely satisfy the minimum requirements of pediatric cases established by the teaching programs.

[Resistance of earthworms Lumbricus terrestris and Allolobophora turgida to the fungicide captan 50 W.P].

Two species of earthworms were kept in Muck, Chicot and Ste-Sophie soils treated with captan 50 W.P. solutions of 700, 1 400 and 2 800 ppm.