Chronic renal failure and anterior hypophysial hormones.

Kidneys are not only organs with an excretory function but they produce their own endocrine factors which are involved in supporting homeostasis in the organism. The kidneys are the organs in which metabolism and biodegradation of many hormones take place. Together with the liver, the kidneys actively take part in the catabolism of hormones.

Influence of dopamine energic pharmacology drugs on secretion of the adrenocorticotropic hormone from the hypophysis.

To elucidate the role of dopamine as a neuromediator in the adrenocorticotropic hormone (ACTH) secretion, investigations were carried out with dopaminergic pharmacology drugs on male white Wistar rats. In the first series of experiments, the effects of 200 mg/kg body wt L-DOPA, of the combination of 200 mg/kg L-DOPA and 50 mg/kg body wt carbidopa, and of 2.5 mg/kg body wt bromocriptine, after a single intraperitoneal injection of ACTH in the serum of rats after 30, 90 and 120 min, following the injection, were studied.

[A comparative study of the effect of Zoladex treatment versus orchiectomy in patients with advanced prostatic cancer].

The study entered sixty patients with advanced carcinoma of the prostate that were treated and followed-up by the authors. The median age was 70.3 years (range 58-83 years).

[Progesterone receptors in patients with endometrial cancer].

The authors investigate the Prog. receptors in 62 women with carcinoma endometrii. They relate their findings to the age of the patients, clinical stage and the histological differentiation of the tumors.

[The formulation of the current management of patients with atypical hyperplasia (AH)].

The authors study is the receptor status of 16 patients with AH. The amount of ER and PR in patients with AH is compared to the amount of the same receptors in patients with highly differentiated adenocarcinoma. A progestin treatment is proposed for AH together with dynamic evaluation of the amount of ER and PR.

[Estrogen and progesterone receptors as prognostic markers in endometrial carcinoma].

The authors examined the concentration of ER and PR in malignant endometrium and compared them to the survival of the patients with endometrial carcinoma. The results were 55.5% positive ER and 44.

[The effect of E2 and progesterone on the receptor status in endometrial carcinoma].

The authors study the plasma levels of E2 and progesterone in 62 women with EC. Parallelly the ER and PR in the same number of cases have been studied. The values of E2 in the plasma of ER+ are much lower than those of E2 in ER-.

[The tumor markers CEA, AFP and CA125 in patients with endometrial carcinoma].

The plasma concentration of CEA, AFP and CA125 in 54 women with endometrial carcinoma and 12 with atypical hyperplasias, were investigated. In 20 of the patients the tumor markers were studied again 11 months after the surgical treatment. Elevation of CEA, AFP and CA125 levels was found in the third, and especially in the forth phase of the illness.

[Clinical significance of analysis of estrogen and progesterone receptors in human uterine tissues].

The action of steroid hormones in the target cell was found to be associated with the presence of specific receptors in the cytoplasm. Uterine, endometrial, and myometrial tissues obtained at hysterectomy for endometrial carcinomatosis and fibromyomas were used. In fibromyomas, the estrogen and progesterone receptors were found to be higher in the cytosol than in the normal myometrium.

[A parallel study between the magnitude of smooth-muscle contraction in vitro and the prostanoid content of the incubation medium of the preparation after the introduction of blood serum from women].

An attempt is made to establish dependence between stimulation of smooth-muscle contraction and the concentration of prostanoids in biologically active sera of women on the basis of two various methods: physiological test with smooth-muscle strips in vitro and radioimmunological determination of prostanoids. Three prostanoids are examined PgF2 alpha PgI2, TxA2 are examined and it is found that lineal dependence between the prostanoid concentration and activation of contraction (for the whole range) is observed only for PgF2 alpha, which allows graphic interpolation for this prostaglandin.

Stress-induced changes in the cyclic nucleotide concentrations and phosphorylase activity in the myocardium.

Restraint stress was produced by immobilizing rats in supine position for 6, 12 and 24h. Control rats were deprived of food and water for the same time intervals. Concentrations of cyclic AMP and cyclic GMP and activity of glycogen phosphorylase were studied in the ventricle myocardium of the animals.

[Changes in the thromboxane B2 level of the blood plasma following partial resection of the pancreas].

The present study was devoted to the still poorly exploited aspect of pancreas surgery, from a standpoint of postoperative divergences in the plasma prostaglandin level. Experiments were carried out with dogs. The authors apply proximal (right) resection of pancreas and eliminate the exocrine function of the remaining part by occlusion of the pancreatic canal.

[The carcinoembryonic antigen in chronic pancreatitis].

The fasting carcinoembryonal antigen (CEA) concentrations in the serum and duodenal juice and after venous stimulation of the exocrine pancreas with the hormones CCK and secretin (Boots) were studied. Radioimmunologic test with a kit of the firm "Labimex"--PPR was used. 28 patients with clinically proved chronic pancreatitis and a control group of 27 healthy persons were examined.

[The differential diagnosis of hairy virilism in polycystic ovaries from adrenal cortical hirsutism].

The hormones on the axis hypophysis-ovary and hypophysis-suprarenal gland were examined in 60 women with polycystic ovaries and hairy virilism, 53 women with hirsutism and 45 healthy women, all of the same age. The results show that in hairy virilism from ovarian origin the luteinizing hormone level (LH) is increased 100% and the follicle stimulating hormone level (FSH) is decreased 200%. The index LH/FSH is increased more than 3 times.

[Changes in the ACTH and cortisol values of patients with acute myocardial infarct].

The plasma cortisol and adrenocorticotrophic hormone (ACTH) levels were studied in 12 patients with clinical, laboratory and ECG data for acute myocardial infarction. The changes were followed up during the 1, 3, 8 and 14 day after the onset of the chest pain attack. Increased ACTH and cortisol levels were established in these patients up to the 5 day.

[The concentration of carcinoembryonic antigen and carbohydrate antigen Ca-19-9 in the blood serum in cancerous diseases of the gastrointestinal tract].

The results of comparative investigation of 266 cancer patients, 44 patients with benign G. I. tract diseases and 66 healthy subjects using 2 tumor markers (CEA and Ca-19-9) showed the diagnostic value of both methods, not exceeding 38-42%.

[Hormonal aspects in the diagnosis of hirsutism].

Hormones of hypophyseal-adrenal axes were determined in 135 girls with hirsutism. On the basis of changes in the hormonal levels it was established that the syndrome of Stein-Leventhal in 62 girls (54% of the patients) was dependent on luteinizing hormone (LH) and was characterized by an increased index of LH/FSH over 3.0 as well as by an increased level of testosterone; hirsutism in 73 girls (67% of the patients) was dependent on adrenocorticotropic hormone (ACTH) and was characterized by an increased level of ACTH and cortisol secretion; in the remaining patients hirsutism was a combination of both forms of dependence on LH and ACTH and an increase of hormones of both axes was present or was idiopathic with normal hormonal plasma levels, but with increased skin conversion and metabolic testosterone clearance.

[Changes of laboratory hematologic indices in patients with chronic glomerulopathies following treatment with superhigh doses of cyclophosphamide].

41 patients with active glomerulopathies treated with super high doses of Cyclophosphamide were studied. The following indices were followed up dynamically: hemoglobin concentration, number and morphology of erythrocytes, number and morphology of leucocytes and differential count. Hemoglobin concentration and erythrocyte count remain in the reference ranges in most of the patients.

[A patient with psoriatic arthritis and secondary amyloidosis].

A case of a man suffering from psoriasis vulgaris is presented. The onset of the disease was at the age of 5. From the age of 14 all joints were gradually affected by the type of severe, symmetrical psoriatic arthritis which led to aseptic necrosis of the hip joints.

[Gamma-camera scintigraphy and radioimmunological study of the hormones of the hypophyseal-gonadal axis to evaluate testicular function in patients with hypogonadism and infertility].

Gamma-camera and radioimmunological study of hormones of hypophyseal-gonadal axis were carried out on 34 patients with hypogonadism and infertility after successfully performed orchidopexy. The results from this study showed that gamma-camera scintigraphy was exact and noninvasive method for determining the structure and function of testes after operative intervention. The results of the established hormonal deviations in the secretion of hormones of hypophyseal-gonadal axis are sure and early criterium for diagnosis of infertility in these patients.