Publications by authors named "Miling Ran"

Article Synopsis
  • Dual-specificity phosphatases (DUSPs) are important for regulating immune responses by deactivating specific kinases, but their function in fish like yellow catfish is still not well understood.
  • * In this study, researchers identified eight DUSP genes in yellow catfish and analyzed their molecular characteristics, genetic location, and expression during immune responses.
  • * Results showed conserved features in these genes and indicated that they play a significant role in the catfish's immune response to bacterial infections, which could be useful for aquaculture practices.
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Microplastics (MPs) are pollutants widely distributed in the aquatic environments and causing various degrees of aquatic toxicity to aquatic organisms, which has attracted global attention in recent years. Nano-selenium (NSe) has been shown to have the potential to mitigate the harmful impacts of toxic substances. However, there is currently no reported evidence regarding the protective influence of NSe against the adverse effects of MPs.

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Article Synopsis
  • Aeromonas hydrophila causes motile Aeromonas septicemia (MAS) in freshwater fishes like yellow catfish, affecting their kidney, which plays a crucial role in immune response.
  • The study used single-cell RNA sequencing (scRNA-seq) on the kidneys of infected hybrid yellow catfish to identify nine cell types and analyze immune response mechanisms.
  • Findings showed that after infection, macrophages exhibited increased activity in Toll-like and Nod-like receptor pathways, suggesting important cellular changes that enhance understanding of kidney immunity in these fish.
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The yellow catfish (Pelteobagrus fulvidraco) is one of the most economically important freshwater species in Asia. However, pathogenic bacterial infections often cause high rates of mortality and economic losses in practical aquaculture. Previous studies in mammals have shown that Toll-like receptor 2 (TLR2) and Toll-like receptor 5 (TLR5) are involved in the recognition of cell wall components such as lipopolysaccharides and flagella of various bacteria, thereby acting as key regulators in the innate immunity response.

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