Publications by authors named "Milind D Ronghe"

Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we analysed all five loci in 120 Wilms tumors. We identified epigenetic 11p15 abnormalities in 69% of tumors, 37% were H19 epimutations and 32% were paternal uniparental disomy (pUPD).

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Article Synopsis
  • Constitutional abnormalities at the 11p15 growth regulatory region are linked to growth disorders and increase the risk of developing Wilms tumor, a type of kidney cancer.
  • In a study of 437 sporadic Wilms tumor cases, 3% showed 11p15 abnormalities, particularly in those with bilateral tumors, highlighting a potential genetic factor.
  • The findings suggest that 11p15 analysis should be routinely conducted in Wilms tumor patients for better understanding and management of the disease.
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Thromboembolic disease (TED) is increasingly recognized as a major cause of morbidity and mortality in tertiary pediatrics. Children younger than 1 year of age and teenage girls are at greatest risk of thromboembolism. Although anticoagulation therapy is the treatment of choice for TED, the treatment strategy is often difficult, especially in children.

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The impact of transfusion of leucodepleted platelet concentrates (PCs) on cytomegalovirus (CMV) disease was assessed in 215 allogeneic (145 unrelated and 70 related donor) transplants over 3 years. In 43%, both donor and patient were CMV seronegative (CMV-/-). All received CMV-seronegative red cells and random leucodepleted PCs.

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