Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives.

Both amyloid-β (Aβ) and transition metal ions are shown to be involved in the pathogenesis of Alzheimer's disease (AD), though the importance of their interactions remains unclear. Multifunctional molecules, which can target metal-free and metal-bound Aβ and modulate their reactivity (e.g.

A rationally designed small molecule for identifying an link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease.

Multiple factors, including amyloid-β (Aβ), metals, and reactive oxygen species (ROS), are involved in the development of Alzheimer's disease (AD). Metal ions can interact with Aβ species generating toxic oligomers and ROS ; however, the involvement of metal-Aβ complexes in AD pathology remains unclear. To solve this uncertainty, we have developed a chemical tool () that specifically targets metal-Aβ complexes and modulates their reactivity (, metal-Aβ aggregation, toxic oligomer formation, and ROS production).