Publications by authors named "Milica Gulic"
The hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a major regulator of adaptive response to hypoxia, common in patients with severe coronavirus disease 2019 (COVID-19). In addition, HIF-1 alpha regulates the expression of the most important proteins necessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of cells. The study included 129 hospitalized COVID-19 patients.
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- MMPs and TIMPs play a role in the effectiveness of rtPA therapy for patients with acute ischemic stroke (AIS) and can also influence recovery and adverse effects.
- The study aimed to investigate whether specific genetic variations in the MMP-2, MMP-9, and TIMP-2 genes affect the response to rtPA treatment and the occurrence of side effects in AIS patients.
- Findings indicated no direct link between these genetic variations and therapy outcomes, but the TT genotype of the MMP-9-1562C/T polymorphism was associated with increased risk of serious complications like intracranial hemorrhage following rtPA treatment.