Publications by authors named "Milene V S Sobral"
Introduction: Recent studies have demonstrated an association between hypoglycemic medications and neuroprotective action in neurodegenerative diseases, such as Parkinson's disease (PD). Therefore, in this meta-analysis, our objective was to evaluate the efficacy of these medications, compared to placebo, as disease-modifying therapy in patients with PD.
Methods: We systematically searched PubMed, Embase, and Cochrane for studies comparing the use of hypoglycemic drugs and placebo in patients with PD.
Efficacy and Safety of Inhibitors of the Proximal Pathway of the Complement System in Paroxysmal Nocturnal Hemoglobinuria: A Meta-analysis of Randomized Controlled Trials.
Am J Ther
October 2024
Article Synopsis
- A systematic review compared the effectiveness and safety of oral versus topical minoxidil in treating androgenetic alopecia, analyzing data from four randomized clinical trials involving 279 patients.
- The study found no significant differences between the two forms of minoxidil regarding hair density and diameter, suggesting both treatments are similarly effective.
- However, oral minoxidil resulted in a higher occurrence of hypertrichosis (excess hair growth), while the incidence of hypotension was not significantly different between the two groups.
Assessing the efficacy of oral tranexamic acid as an adjuvant to triple combination topical treatment in melasma: a meta-analysis of randomized controlled trials.
Clin Exp Dermatol
November 2024
Melasma is a skin pigmentation disorder that lacks consistent treatment success, despite various methods used. Tranexamic acid (TXA) has shown hypopigmentation properties, but whether its administration should be combined with standard treatment has yet to be clarified. We aimed to perform an investigation of the effectiveness and safety of oral TXA as an adjuvant to triple combination cream (TCC) treatment in melasma.
View Article and Find Full Text PDFCertain guidelines recommend a second-generation H1-antihistamine (AH) as first-line treatment for patients with chronic urticaria (CU). However, some patients show insufficient response to a standard dose of this therapy and might benefit from adding leukotriene receptor antagonists (LTA). Therefore, we aimed to perform a systematic review and meta-analysis comparing LTA plus antihistamines with antihistamines alone.
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