Publications by authors named "Milena Zambetti"
Article Synopsis
- Desmoplastic melanoma (DM) is a rare melanoma subtype that responds well to immune checkpoint inhibitors (ICIs), but it can cause serious side effects.
- A case study of a 53-year-old man showed that despite achieving a complete response to a combination of anti-CTLA-4 and anti-PD-1 antibodies, he experienced significant immune-related adverse events, including thyroid and adrenal issues.
- The findings highlight the need for careful monitoring of patients undergoing ICI therapy for DM to manage both the treatment's effectiveness and its adverse effects.
Mucosal high-risk (HR) human papillomaviruses (HPV) are associated with anogenital carcinogenesis. The products of two early genes, E6 and E7, act as major viral oncoproteins. Functional studies in experimental models showed that HPV16 E6 induces degradation of the PDZ protein, the Na+/H+ exchanger regulatory factor-1 (NHERF-1).
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