Publications by authors named "Milena Franco"
Article Synopsis
- A study measured mitochondrial DNA copy numbers in blood cells of 34 patients with acute intermittent porphyria (AIP) and 37 healthy individuals, revealing low mitochondrial counts in AIP patients.
- The reduction in mitochondrial content was linked to the condition's pathogenesis, suggesting a protective mechanism against heme synthesis deficiency.
- The findings indicate that mitochondrial proliferation may influence how AIP symptoms manifest, and highlight mtDNA levels and mitochondrial biogenesis as potential biomarkers for the disease.
The interplay between calcium metabolism and glycosylation in yeast is largely unknown. In order to clarify this relationship, the effect of a mutation in the KlOCH1 gene, encoding the Golgi α-1,6-mannosyltransferase, on calcium homeostasis was studied in the yeast Kluyveromyces lactis. In particular, the role of the KlMID1 gene, encoding one of the components of the plasma membrane calcium channel (Cch1-Mid1), was investigated.
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