Publications by authors named "Milena Deal"
Article Synopsis
- Research on abdominal obesity highlighted that the rs10494217 variant in the TBX15 gene is linked to adipocyte health and the heritability of obesity.
- The frequency of this variant shows a geographical trend, decreasing from north to south, particularly evident in the Finnish population, suggesting an adaptive response to colder climates.
- Individuals with the risk allele exhibit changes in gene expression related to thermogenesis and unhealthy fat cell growth, indicating the variant's possible role in promoting abdominal obesity.
Background: Age and obesity are dominant risk factors for several common cardiometabolic disorders, and both are known to impair adipose tissue function. However, the underlying cellular and genetic factors linking aging and obesity on adipose tissue function have remained elusive. Adipose stem and precursor cells (ASPCs) are an understudied, yet crucial adipose cell type due to their deterministic adipocyte differentiation potential, which impacts the capacity to store fat in a metabolically healthy manner.
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