Publications by authors named "Milena Barf"
Article Synopsis
- The rat protoparvovirus H-1 (H-1PV) is known for its anticancer effects in human tumors, particularly non-Hodgkin lymphomas (NHL), but its impact on T-cell malignancies has been less studied.
- A pilot study showed that H-1PV successfully infected and induced cancer cell death in cutaneous T-cell lymphoma (CTCL) models, while not affecting healthy cells, and even increased immune cell infiltration in cancer spheroids.
- The findings suggest that H-1PV could be a promising new treatment option for CTCL, highlighting its potential as a viroimmunotherapeutic candidate.
Glioblastoma, one of the most aggressive primary brain tumors, is characterized by highly immunosuppressive microenvironment. This contributes to glioblastoma resistance to standard treatment modalities and allows tumor growth and recurrence. Several immune-targeted approaches have been recently developed and are currently under preclinical and clinical investigation.
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