Thoracic radiation increases the risk of accelerated coronary artery disease, leading to concerns about outcomes for patients who undergo revascularization after such treatment.
A meta-analysis of four studies involving nearly 14,000 patients revealed a significant increase in all-cause mortality for patients with prior thoracic radiation during percutaneous coronary intervention (PCI), but no significant differences were found for cardiac mortality, myocardial infarction, or restenosis.
The findings suggest that the higher mortality risk in these patients may be more related to their underlying cancer than the effects of the revascularization procedure itself.