[Is there a place for prophylactic fimbriectomy followed by delayed ovariectomy?].

Risk reducing salpingo-oophorectomy has long been the gold standard for preventing the development of tubo-ovarian cancers in high-risk population such as BRCA1/2 mutation carriers. Although a clear survival benefit has been demonstrated of these prophylactic procedures, important side effect from the associated surgical menopause have been described. Given that recent evidence suggests that most high-grade serous carcinomas (HGSC), the majority of all ovarian carcinomas, and especially for patients with a genetic predisposition originate in the fallopian tube, where also precursor lesions such as STIC can be found, an alternative risk reduction strategy has emerged, the prophylactic fimbriectomy with delayed oophorectomy.

Validation Of A Novel Respiratory Monitoring Method and System Based on Antenna Sensors and Optical Tracking of Chest Motion.

The effectiveness of a wearable sinusoidal dipole antenna sensor in monitoring respiratory activity is investigated. An experimental setup combining the antenna sensor and a highly accurate optical tracking system is utilized, and a strong correlation between the antenna's reflection signal and the optical tracker is demonstrated during various respiratory behaviors. Obtained results show the antenna sensor's high accuracy in detecting respiratory cycles, amplitudes, and identifying sleep apnea events.

Compact Grism-Based High-resolution Colorimetric Sensing System for Liquid Samples.

In this work, we propose a semi-autonomous device to measure the absorbance spectrum of a sample with high spectral resolution and high intensity precision to address the previously mentioned issues. The proposed system includes integrated optical, microfluidic and electronic modules. The optical module is based on a polychromator spectrophotometer using a Grism diffractive component for a high spectral resolution.

Advanced generative adversarial network for optimizing layout of wireless sensor networks.

The best layout design related to the sensor node distribution represents one among the major research questions in Wireless Sensor Networks (WSNs). It has a direct impact on WSNs' cost, detection capabilities, and monitoring quality. The optimization of several conflicting objectives, including as load balancing, coverage, cost, lifetime, connection, and energy consumption of sensor nodes, is necessary for layout optimization.

Transferable deep learning with coati optimization algorithm based mitotic nuclei segmentation and classification model.

Image processing and pattern recognition methods have recently been extensively implemented in histopathological images (HIs). These computer-aided techniques are aimed at detecting the attentive biological markers for assisting the final cancer grading. Mitotic count (MC) is a significant cancer detection and grading parameter.

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry.

Neurotransmitter analysis plays a pivotal role in diagnosing and managing neurodegenerative diseases, often characterized by disturbances in neurotransmitter systems. However, prevailing methods for quantifying neurotransmitters involve invasive procedures or require bulky imaging equipment, therefore restricting accessibility and posing potential risks to patients. The innovation of compact, in vivo instruments for neurotransmission analysis holds the potential to reshape disease management.

XRF online analyzer for measurements of PO content in phosphate slurry.

Online X-ray Fluorescence (XRF) setup was constructed and optimized for analysing the PO content in phosphate slurry (PS). Serval samples were analysed using two configurations of the setup, one with low and vertical flow and another with high and horizontal flow. The mean absolute error achieved through the first configuration was 0.

Efficiency and Accuracy Evaluation of Multiple Diffusion-Weighted MRI Techniques Across Different Scanners.

Background: The choice between different diffusion-weighted imaging (DWI) techniques is difficult as each comes with tradeoffs for efficient clinical routine imaging and apparent diffusion coefficient (ADC) accuracy.

Purpose: To quantify signal-to-noise-ratio (SNR) efficiency, ADC accuracy, artifacts, and distortions for different DWI acquisition techniques, coils, and scanners.

Study Type: Phantom, in vivo intraindividual biomarker accuracy between DWI techniques and independent ratings.

French cohort of children and adolescents with neurofibromatosis type 1 and symptomatic inoperable plexiform neurofibromas: CASSIOPEA study.

Surgery is a treatment option for neurofibromatosis type 1 (NF1)-related plexiform neurofibromas (PN), but complete resection is often not feasible. Real-world studies are warranted to understand disease burden, progression, and need for medical treatment in patients with inoperable PN. CASSIOPEA was a retrospective study of French pediatric patients (aged ≥3 to <18 years) presenting at a national multidisciplinary team (MDT) review with NF1 and ≥1 symptomatic, inoperable PN.

The effect of particle size and water content on XRF measurements of phosphate slurry.

Phosphate slurries are studied using the XRF technique and the effect of the particle sizes and the water content parameters are analyzed and reported for the first time. Samples of the phosphate slurry with different particle sizes (425 µm, 300 µm, 250 µm, 200 µm, 160 µm and 106 µm) and different water contents (30%, 40%, 50%, 60%) were analyzed using an energy-dispersive X-ray spectrometer (EDXRF). The results show that the relative error of measurement varies with the particle size of the analyzed sample, the water content and the element measured.

Unusual presentation in amyloidosis.

We report a case of osteolytic polyarthritis and atlanto-axial lesion revealing multiple myeloma-associated amyloid arthropathy in a 56-year-old man. Only histological exam of the salivary gland biopsy demonstrating the presence of amyloid deposits stained with congo red could confirm the diagnosis.

Wearable Sensor Based on Flexible Sinusoidal Antenna for Strain Sensing Applications.

A flexible sinusoidal-shaped antenna sensor is introduced in this work, which is a modified half-wave dipole that can be used for strain sensing applications. The presented antenna is an improved extension of the previously introduced antenna sensor for respiration monitoring. The electrical and radiative characteristics of the sinusoidal antenna and the effects of the geometrical factors are studied.

Towards an advanced neurotechnological system: colorimetric sensing with a novel grism-based spectrometer, functionalized gold nanoparticles and a heterogeneous embedded system.

Neurotransmitter sensing in the brain is crucial for the understanding of neuro-degenerative diseases. Most modern methods for the purpose rely on bulky instruments or are disruptive to the neurotransmitter medium. In this work, we describe and evaluate the design of a novel, compact and non-invasive instrument for neurotransmitter detection based on the colorimetric sensing method.

Lower p66Shc promoter methylation in subjects with chronic renal failure.

Objective: To determine the correlation between DNA methylation of p66Shc promoter and some markers of inflammatory and oxidative stress in chronic renal failure (CRF) patients compared with healthy subjects.

Methods: An observational cross-sectional study was conducted in the nephrology department at Sidi Bouzid Regional Hospital (Tunisia). In total, 39 patients with CRF and 37 healthy subjects were included.

Microscope-FTIR Spectrometry Based Sensor for Neurotransmitters Detection.

In this work, we present a new sensing approach for aqueous samples based on the microscope-FTIR spectrometer and applied for neurotransmitters. Our contribution in this work consists of a new sample handling system for the microscope-FTIR spectrometer based on a total reflective mirror, a heated hydrophobic layer for solvent removal/evaporation and sample confinement and a microfluidic system that handles sample injection unlike standard sample handling system which was based only on a total reflective mirror. In addition, another part of our contribution consists of proposing a new algorithm to extract molecular composition of the solution with high estimation ratios and based on the analysis of detected peaks on IR spectra.

Controlling Growth of Poly (Triethylene Glycol Acrylate--Spiropyran Acrylate) Copolymer Liquid Films on a Hydrophilic Surface by Light and Temperature.

A quartz crystal microbalance with dissipation monitoring (QCM-D) was employed for in situ investigations of the effect of temperature and light on the conformational changes of a poly (triethylene glycol acrylate--spiropyran acrylate) (P (TEGA--SPA)) copolymer containing 12-14% of spiropyran at the silica-water interface. By monitoring shifts in resonance frequency and in acoustic dissipation as a function of temperature and illumination conditions, we investigated the evolution of viscoelastic properties of the P (TEGA--SPA)-rich wetting layer growing on the sensor, from which we deduced the characteristic coil-to-globule transition temperature, corresponding to the lower critical solution temperature (LCST) of the PTEGA part. We show that the coil-to-globule transition of the adsorbed copolymer being exposed to visible or UV light shifts to lower LCST as compared to the bulk solution: the transition temperature determined acoustically on the surface is 4 to 8 K lower than the cloud point temperature reported by UV/VIS spectroscopy in aqueous solution.

The Relationship Between Menopause and Metabolic Syndrome: Experimental and Bioinformatics Analysis.

Menopausal hormonal changes have been associated with the emergence of the metabolic syndrome (MetS) and its consequences such as type 2 diabetes (T2D) and cardiovascular diseases (CVD). The common gene signature and the associated signaling pathways of MetS, T2D, CVD and menopause status have not been widely studied. We analyzed a total of 314 women aged between 35 and 75 years.

Is imagery distinctive in papillary renal cell carcinoma subtypes?

Introduction: The subdivision into two entities of papillary renal cell carcinoma (PRCC) was established on histological criteria. It's in fact possible to distinguish the two subtypes by the means of radiological and progressive data. The subtype 1 is associated with the favorable profile.

A Compact Visible Light Spectrometer for Molecular Detection with Spherical Gold Nanoparticles.

Spectrometers are widely used in molecular detection. However most of them are bulky, power consuming, and quite expensive. This work presents the prototype of a compact visible spectrometer alternative that is battery-operated, and designed for autonomous operation and quick spectrum detection.

Biochemical parameters and oxidative stress markers in Tunisian patients with periodontal disease.

Background: Oxidative stress is involved in many diseases including diabetes and cancer. Numbers of studies have suggested its involvement in the pathogenesis of periodontal diseases. The aim of this study was to evaluate the levels of biochemical parameters and oxidative stress markers in plasma of healthy and chronic periodontitis patients.

Masson's tumor of the kidney: a case report.

Background: Intravascular papillary endothelial hyperplasia (known also as Masson's tumor) is a benign vascular lesion that commonly occurs in the skin and is rarely found in solid organs, especially in the kidney. In what follows, we will look into the first case of an unexpectedly diagnosed Masson's tumor of the kidney presenting as a suspicious renal cyst.

Case Presentation: A 61-year-old Arab man presented with a left renal cyst, incidentally revealed by ultrasonography.

Microfluidic Spectrophotometer for Neurotransmitter Detection Based on Gold Nanoparticles: Preliminary Results.

A microfluidic-based spectrophotometer for neurotransmitters sensing is presented in this paper. In addition, a neurotransmitter photo-fingerprint is analyzed to evaluate the feasibility of selective neurotransmitter detection using optical techniques. The aim of this work is to detect major neurotransmitters (NTs) using a compact, portable and cost effective optical system for selective and real time NT concentration monitoring.

Pseudo-Continuous Flow FTIR System for Glucose, Fructose and Sucrose Identification in Mid-IR Range.

In this paper, we present a new FTIR-based microfluidic system for Glucose, Fructose and Sucrose detection. The proposed microfluidic system is based on a pseudo-continuous flow coupled to a microscope-FTIR instrument. The detection and characterization of sugar samples were performed by recording their absorption spectrum in the wavelength range 700⁻1000 cm - 1 of the Mid-IR region.