Publications by authors named "Mildrey Mosquera-Escudero"
Article Synopsis
- The study aimed to explore how a specific metabolomic profile can help diagnose localized prostate cancer by examining various biological samples.
- Researchers analyzed a total of 1248 studies, narrowing down to 14 case-control studies that primarily focused on serum metabolite analysis, revealing significant associations with certain metabolites.
- The findings indicated that disruptions in the metabolism of fatty acids, amino acids, nucleotides, and steroid hormones are linked to localized prostate cancer, with notable increases in amino acids like glutamate and aspartic acid, and decreases in glycine and serine.
Goiter, iodine bioavailability and intrauterine growth restriction in Indigenous and Afro-descendant pregnant women from six non-metropolitan areas of Colombia (2019-2020).
Rural Remote Health
September 2024
Article Synopsis
- * The research involved 318 pregnant women, predominantly Indigenous, revealing that 23.3% had goiter and 14.9% showed iodine deficiency, with a significant link between literacy and lower iodine deficiency rates.
- * The findings indicate a concerning prevalence of goiter and iodine deficiency, especially in the Cauca region, highlighting the need for targeted public health interventions in these communities.
The antitumor potential of proteins from snake venoms has been studied in recent decades, and evidence has emerged that phospholipases A can selectively attack cells of various types of tumors. Previous results have shown that phospholipase A ", isolated from snake venom, displayed antitumoral activity on cervical cancer and did not alter the viability of non-tumorigenic cells. However, until now, there was no evidence of its safety at the local and systemic levels, nor had experiments been developed to demonstrate that its production using recombinant technology allows us to obtain a molecule with effects similar to those generated by native phospholipase.
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- - Advances in chemotherapy for cervical cancer often harm patients' quality of life, creating a need for safer, natural therapy alternatives.
- - A phospholipase A type-Asp49 from snake venom shows selective toxicity against cervical cancer cell lines (HeLa and Ca Ski) without damaging their membranes.
- - The study concludes that this compound disrupts cell adhesion and affects survival pathways, positioning it as a promising candidate for developing effective cervical cancer treatments.
Aim: To determine the relationship of lipoxin levels with inflammation and disease development in adults and children.
Methods: We conducted a systematic review. The search strategy included Medline, Ovid, EMBASE, LILACS, The Cochrane Central Register of Controlled Trials, and Open Gray.
Expression of Circulating MicroRNAs Associated with Obesity and their Relationships with Biochemical Parameters and Health-related Physical Fitness in Children 6 to 10 Years Old in Cali, Colombia.
Microrna
March 2023
Background: Obesity is a public health problem worldwide; it has reached pandemic proportions in the last 40 years. Its prevalence in children and adolescents increased from 0.7% to 7.
View Article and Find Full Text PDFDue to the lack of chemotherapeutic drugs that selectively affect cervical cancer cells, natural sources such as snake venom are currently being investigated for molecules with antitumor potential. , a phospholipase A type-Asp49 from snake venom, induced cell death in a cervical cancer cell line-Ca Ski-related to dysfunction in the ability to resolve endoplasmic reticulum stress, evidenced by sub-expression of genes such as PERK, ERO1 PDIs, HSP70, and CHOP. Western blot analysis validated the last two genes' sub-expression at the protein level.
View Article and Find Full Text PDFBackground: Circulating microRNAs (miRNAs) are one of the most abundant classes of gene regulatory molecules, and had been associated to the metabolic syndrome, higher BMI, dyslipidemia and diabetes mellitus. In this sense, miRNAs could help to understand the mechanism behind the development of metabolic syndrome.
Objective: To determine the relationship between circulating microRNAs and the metabolic syndrome in adult population.
Background: Overweight and obesity prevalence has risen substantially in the last years. MicroRNAs (miRNAs) are factors that regulate gene expression through binding to a complementary sequence of mRNA.
Objective: The objective of this review is to determine the association between the expression of miRNAs with overweight and obesity in children.
Objective: To assess age- and sex-specific percentile baseline data for total cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) in Colombian children and adolescents aged 10 to 17 years.
Patients And Methods: A cross-sectional, descriptive study was conducted on 1,773 children and adolescents. Each participant underwent a fasting measurement to quantify TC, HDL-C, and TG levels using enzymatic-colorimetric methods.
Article Synopsis
- The study aimed to assess how regular aerobic exercise impacts endothelial function and cardiorespiratory fitness in pregnant women.
- A total of 64 healthy first-time pregnant women participated, with one group doing specific aerobic workouts and the control group maintaining their usual activity over 16 weeks.
- Results showed that those who exercised had significantly better cardiorespiratory fitness and improved vascular function compared to the control group, indicating exercise could help prevent issues linked to endothelial dysfunction during pregnancy.
Question: Does supervised aerobic exercise during pregnancy improve health-related quality of life in nulliparous women?
Design: Analysis of secondary outcomes of a randomised trial with concealed allocation, blinded assessors, and intention-to-treat analysis.
Participants: 64 nulliparous, pregnant women attending for prenatal care at one of three tertiary hospitals.
Intervention: The experimental group completed a 3-month supervised exercise program, commencing at 16 to 20 weeks of gestation.
Postprandial lipemia has been associated with atherogenesis and other non infectious chronic diseases. A descriptive, non aleatory study of 51 healthy young adults (23.8 +/- 4 years) of different ethnic background was carried out to identify possible personal or life style factors associated with the response of plasma lipids after a mixed carbohydrate and lipid load.
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