Publications by authors named "Milda Naciute"
Bacteria biohybrid-based vaccine delivery systems, which integrate a vaccine carrier with live non-pathogenic bacteria, are hypothesized to have improved immunostimulating potential. The aim of this study was to develop oral bacteria biohybrid-based vaccines to treat a mouse model of colorectal cancer. E.
View Article and Find Full Text PDFThe aim of this study was to develop an oral vaccine that could be used to treat colorectal cancer. Oral vaccines are technically challenging to develop due to the harsh gastric environment but have numerous benefits including high patient acceptability and the potential to stimulate local mucosal immune responses. Therapeutic vaccines are being investigated as options to treat cancer and the generation of local mucosal immunity may be of benefit in the treatment of gastrointestinal cancers.
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- The study aimed to examine different T-cell subpopulations in the blood of rheumatoid arthritis patients who are either positive or negative for human parvovirus B19, along with healthy individuals.
- Blood samples from 115 RA patients and 47 healthy participants were analyzed using flow cytometry to measure levels of certain T-cell markers (CD4, CD8, CD25, and CD45RA).
- Results showed that patients with B19-positive RA had higher levels of regulatory T-cells compared to those who were B19-negative and healthy controls, suggesting a possible link to persistent viral infections.
Background: Parvovirus B19 (B19V) infection is associated with various autoimmune diseases. We investigated the levels of pro-inflammatory (IFNᵧ, TNFα, IL-2, IL-12) and anti-inflammatory (IL-4, IL-10) cytokines in the plasma of B19V DNA positive (B19) and negative (B19) rheumatoid arthritis (RA) patients in comparison with the control group (healthy persons).
Methods: Blood samples were collected from 118 patients with RA and 49 healthy voluntaries.
The present study aims to clarify the possible involvement of parvovirus B19 (B19V) infection in rheumatoid arthritis (RA) pathogenesis by investigating the presence of B19V infection markers (genomic sequences and virus-specific antibodies) in association with the level of cytokines and RA clinical activity and aggressiveness. A total of 118 RA patients and 49 age- and sex-matched healthy volunteers were enrolled in the study. Nested PCR was used to detect B19V sequences in whole blood and cell-free plasma DNA, ELISA to detect virus-specific antibodies and cytokine levels in plasma and recomLine dot blot assay for antibodies to separate B19V antigens.
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