The clinical forms of systemic neuroendocrine pathology (neuroendocrine cybernosis).

Six forms of regulation of neuroendocrine system pathology are here presented. For this pathogenic category it was proposed the term of "systemic neuroendocrine pathology" (1979) and that of "endocrine cybernosis (1971) for its clinical forms. Clinical and pathogenic peculiarities of endocrine blocking cybernoses with negative feed-back disappearance, substitution cybernose as in Graves-Basedow's syndrome and hormonal circadian rhythm troubles are described.

Blocking cybernosis in endocrine glands pathology.

The term cybernosis was proposed by Meerloo (1971) in order to designate the cybernetic functional disorders in senescence. Blocking cybernosis or bloking negative feedback is the term used for negative feedback perturbation in a neuro-endocrine subsystem caused by factors dwelling inside or outside it. Using the hypothalamo-hypophyso-adrenocortical subsystem as a model, the author shows that due to an excessive and anarchic secretion of corticoids by a tumor developed in the adrenocortical, the hypothalamo-hypophyseal control centers are blocked.

Tuberculous thyroiditis cured by drug therapy.

A 73-year-old patient suffering from evolutive nodular goiter, free of other local complaints or changes in the general status is presented. A diagnosis of tuberculous thyroiditis with hypothyroidism is reached. This diagnosis is justified by the antecedents of the patient, positive IDR, low iodine uptake, characteristic scintigraphic and echographic picture of the thyroid.

Research on the radioprotecting action of thymic polypeptides and timosterin B.

Administration of the TP2 polypeptidic thymic extract results in normalization of the rosette-forming capacity of the T spleen cells in the X-ray irradiated mouse. The radioprotecting effect was also noticed on the inhibition of macrophages migration in the X-ray irradiated rat inoculated with TH Salmonella typhi vaccine and treated with TP2 or with lipidic extract Timosterin B.

Action of thymic polypeptides of low molecular weight on some immune reactions at tissular and humoral level in guinea-pigs and mice.

Administration of the TP2 extract containing thymic polypeptides of low molecular weight (under 10,000 daltons) was found to stimulate the delayed hypersensitivity reaction in guinea-pigs injected with BCG. It was also found to reduce the hemagglutination titre in mice injected with the APR 8 influenza virus and to raise the antiflagellar agglutinins titre in rats injected with TH Salmonella vaccine. The cellular type of immune reactions was stronger than the humoral one.

Morphology of T and B lymphocytes assessed by scanning electron microscopy (SEM) in thyroiditis and Graves's disease.

Scanning Electron Microscopy (SEM) assessment of the T and B lymphocytic sub-population shows alterations in cell immunity in the thyroid gland pathology. The mean per cent figure in 10 normal individuals was 68.8 for T lymphocytes (variation range: 50-83%) and 19.

Circadian rhythms of corticosterone and nucleic acids in the rat adrenal in relation to age.

For 3 successive days, at 0600, 1200, 1800 and 0000, the circadian variations of corticosterone, RNA and DNA were followed up in the adrenals of 3 lots of prebuertal (30 days old), adult (120 days old) and old (28 months old) white Wistar male rats. There is a correlation between the circadian rhythm of corticosterone secretion and the circadian rhythms of RNA and DNA synthesis all along ontogenesis. These rhythms appear to be formed at 30 days of life, but they still differ from the ones in the adult rats by the levels recorded in the second half of the nocturnal period.

Changes in the bioelectric activity of the lateral septal nucleus, dorsal hippocampus and medial habenular nucleus after administration of the pineal peptide extract "crinofizin".

New Zealand rabbits with pairs of electrodes implanted chronically in the RFM, dorsal hippocampus, LSN and HM were tasted for electroencephalographic changes in the dorsal hippocampus, lateral septal nucleus and medial habenular nuclei in response to electric stimulation of the mesencephalic reticular formation and after slow i.v. and i.