A Decision Support Alert for Promoting Prophylactic Laxative Use with Clozapine.

We investigated the effectiveness of a decision support alert to improve prophylactic laxative use with clozapine in hospital. Prescribing data for first clozapine and laxative prescriptions were extracted and linked. Proportions of first clozapine prescriptions for which a laxative was co-prescribed within 24 hours was compared before and after alert implementation.

Optimising interruptive clinical decision support alerts for antithrombotic duplicate prescribing in hospital.

Introduction: Duplicate prescribing clinical decision support alerts can prevent important prescribing errors but are frequently the cause of much alert fatigue. Stat dose prescriptions are a known reason for overriding these alerts. This study aimed to evaluate the effect of excluding stat dose prescriptions from duplicate prescribing alerts for antithrombotic medicines on alert burden, prescriber adherence, and prescribing.

Population pharmacokinetics of oxycodone: Premature neonates to adults.

Background: Oxycodone is used in children and adults for the control of acute postoperative pain. Covariate influences such as age, size, and fat mass on oxycodone pharmacokinetic parameters over the human lifespan are poorly quantified.

Methods: Pooled oxycodone time-concentration profiles were available from preterm neonates to adults.