Publications by authors named "Milan R Dobric"
Long-term follow-up of patients with chronic total coronary artery occlusion previously randomized to treatment with optimal drug therapy or percutaneous revascularization of chronic total occlusion (COMET-CTO).
Front Cardiovasc Med
January 2023
Background: The COMET-CTO trial was a randomized prospective study that assessed long-term follow-up in patients with chronic total occlusion (CTO) in coronary arteries treated with percutaneous coronary intervention (PCI) or with optimal medical therapy (OMT). During the 9-month follow-up, the incidence of major adverse cardiac events (MACE) did not differ between the two groups; no death or myocardial infarction (MI) was observed. There was a significant difference in quality of life (QoL), assessed by the Seattle Angina Questionnaire (SAQ), in favor of the PCI group.
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- The study investigates the effectiveness of measuring coronary flow velocity reserve (CFVR) using transthoracic Doppler echocardiography (TTDE) during dobutamine stress to evaluate myocardial bridging (MB) compared to traditional adenosine methods.
- It includes 81 symptomatic patients with isolated-MB, and aims to establish a CFVR cut-off value that indicates myocardial ischemia linked to MB, validated against exercise-induced wall motion abnormalities (WMA).
- Results show that a CFVR cut-off value of ≤ 2.1 during high-dose dobutamine is optimal for identifying patients with MB associated with stress-induced ischemia, demonstrating high sensitivity and specificity (96% and 95%,
Background Functional assessment of myocardial bridging (MB) remains clinically challenging because of the dynamic nature of the extravascular coronary compression with a certain degree of intraluminal coronary reduction. The aim of our study was to assess performance and diagnostic value of diastolic-fractional flow reserve (d-FFR) during dobutamine provocation versus conventional-FFR during adenosine provocation with exercise-induced myocardial ischemia as reference. Methods and Results This prospective study includes 60 symptomatic patients (45 men, mean age 57±9 years) with MB on the left anterior descending artery and systolic compression ≥50% diameter stenosis.
View Article and Find Full Text PDFThe aim of this randomized prospective study was to evaluate the quality of life (QoL) using the "Seattle Angina Questionnaire" (SAQ) in patients with chronic total occlusion (CTO) in coronary arteries treated with either percutaneous coronary intervention (PCI) or optimal medical therapy (OMT), or only with OMT.The potential benefits of recanalization of CTO by PCI have been controversial because of the scarcity of randomized controlled trials.A total of 100 patients with CTO were randomized (1:1) prospectively into the PCI CTO or the OMT group (50 patients in each group).
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