Pharmacodynamics and common drug-drug interactions of the third-generation antiepileptic drugs.

Anticonvulsants that belong to the third generation are considered as 'newer' antiepileptic drugs, including: eslicarbazepine acetate, lacosamide, perampanel, brivaracetam, rufinamide and stiripentol. Areas covered: This article reviews pharmacodynamics (i.e.

Alcoholic and postoperative delirium: a case-control study.

Background: Delirium is an urgent condition in psychiatry and it occurs after long-lasting alcohol abuse, in surgical procedures and other organic mental syndromes with deprivation of interpersonal and social stimulations. The aim was to evaluate of sociodemographical and psychopathological differences in delirium patients with alcoholand surgical genesis, studied in period from January 1(st) 2003 to December 31(st) 2012 in Bosnia and Herzegovina (B&H).

Subjects And Methods: Subjects were divided into two groups: alcoholics (N=75) and surgical patients (N=75) and multicentric, prospective study was performed in B&H.

[Destructiveness of the perpetrators who have committed crimes and misdemeanors].

Introduction: Destructiveness in aggressive behavior is interpreted as having many causes, the psychiatric ones being of biological, social and psychopathological nature. This study was aimed at examining the differences among the perpetrators who have committed crimes and misdemeanors in Bosnia and Herzegovina in the period from January 1st, 2003 to December 31st, 2012.

Material And Methods: This prospective, multicentric study used the following measuring instruments: list of general data.

[Forensic importance of homicide].

Introduction: This study encompassed the total number of homicides in Bosnia and Herzegovina (B&H) in the period from 1st January 1997 to 31st December 2006 and then analysed homicidal behaviour. The aim is to assess the differences between the people who committed violent and those who committed accidental homicide in Bosnia and Herzegovina.

Material And Methods: In a multicentric, retrospective study of comparing the groups with equal number of respondents we analysed the individuals who had committed violent (n=135) and accidental homicides (n=135).

Effect of furosemide on radioiodine-131 retention in mice thyroid gland.

Retention of iodine in the thyroid gland is the result of renal excretion and transport of iodine to thyroid cells. Both processes are affected by furosemide. The aim of our study was to test whether furosemide influenced radioiodine-131 ((131)I) retention in the thyroid gland of living mice.

[Testament's ability in Balkan endemic nephropathy].

Introduction: Testament is a solemn, authentic instrument in writing, by which a person declares his or her will as to disposal of his or her estate, and it has a psychopathological, lawful and ethical importance to a person, family and society. The aim of the study was to assess if the ability to make a testament was more damaged in patients with Balkan Endemic Nephropathy (BEN) than in patients with other diseases that resulted in Chronic Renal Failure in Bosnia and Herzegovina in the period from the 1st January 2001 to 31st December 2006.

Material And Methods: The 753 respondents were divided into two groups in the study: BEN group (n=150) and control group made of patients with other diseases resulting in CRF (n=150).

Euthanasia of patients with the chronic renal failure.

This study deals with frequency and form of euthanasia in dialysis patients with chronic renal failure (CRF) in Bosnia and Herzegovina (B&H) within the period from 2000 to 2006. Of total number of 2700 patients on dialysis we examined n = 753 of them. Examinees with the Balkan Endemic Nephropathy (BEN) (n = 348) were in the first group, and the Control group was formed of patients with other diseases (n = 405).

Effects of cisplatin and other Pt(II) complexes on spontaneous motility of isolated human oviduct.

The toxicity of platinum(II) ion could be significantly modified by coordination with some organic compounds. In our study, the cytotoxicity and the influence of platinum(II) complexes, such as cisplatin, cis-[PtCl(2)(NH(3))(2)], [PtCl(2)(SMC)] and [PtCl(2)(DMSO)(2)] (where SMC is S-methyl-l-cysteine and DMSO is dimethyl sulphoxide) on spontaneous motility of isolated human fallopian tubes were investigated. Cisplatin showed potent pro-apoptotic effects on peripheral blood mononuclear cells (PBMC).

Anthropological aspect of death in dialyzed patients.

The aim of this article is to compare the incidence of thanatophobia in dialysed patients having Balkan endemic nephropathy (BEN) with a control group (N18) members where some of them have chronic renal failure (CRF), but not (BEN). We examined thanatophobia on a sample of 753 dialysed patients with chronic renal failure (CRF) in Bosnia and Herzegovina (B&H) during the period from 1st January 2000 to 31st December 2006. The first group is a cohort consisted of 348 patients with Balkan endemic nephropathy (BEN), and the control group consisted of 405 randomly selected patients with different diagnoses of CRF (N18).

Somatisation disorder in nephrologic patients.

Introduction: Nephrologic patients have somatisation disorder that can be primary disorder when fear is dominant or secondary disorder in the frame of other organic and mental disorders.

Aim: To evaluate, somatisaton disorder is more offten accompanied with microalbuminuria (MA) in patients with suspected endemic nephropathy than in patients with some other nephrologic disorder, in Bosnia and Herzegovina (B&H) during period from January the 1st of 2000 to December the 31st of 2006.

Method: Somatisation disorders were proved in patients with microalbuminuria (MA) in nephropathic group (n = 200), and they were compared to the patients with MA in other nephrologic disorders (n = 200).

Effects of exogenous glutamate and kainate on electric field-stimulated contractions of isolated human ureter.

Objectives: A neurotransmitter role for glutamate in the autonomous nervous system was recently demonstrated in the gastrointestinal tract, and its stimulatory effect on spontaneous motility of human ureter was shown. The aim of our study was to investigate the effects of glutamate on the release of neurotransmitters from intramural nerves of the human ureter.

Methods: The effects of exogenous glutamate were tested on electric field-stimulated contractions of isolated human ureter, taken from 16 adult patients after nephrectomy.

[Anxiety disorders in dialysis patients].

Introduction: Anxiety, as a primary symptom, includes all conditions of indefinite fear and psychic disorders dominated by fear. All dialysis patients suffer from anxiety as an independent phenomenon, or as part of another disease.

Material And Methods: This study included 753 patients on chronic hemodialysis in Bosnia and Herzegovina (B&H) in the period 1999-2004.

[Influence of mental disorders on working ability assessment].

Background/aim: There is an increasing need for evaluation of working ability due to lower level of social protection of workers and growing number of patients with mental diseases in Bosnia and Herzegovina (B&H). The aim of this study was to establish the influence of mental diseases on the occurrence of disability of I and III categories in B&H during the period from January 1st 2005 to December 31st 2006.

Methods: This study involved 1792 examinees with the complete loss of working ability (I disability category) (n = 921).

[Types of rape victimization].

Introduction: Behavior of rape victims is an enigma associated with the following phenomena: poverty, transition, legal weaknesses, and unintegrated mental health network. The aim of the study was to investigate rape victimization in relation to anomie, stress and postwar transition-related weaknesses in B&H in the period 1996-2005; and perform a personal analysis of rape victims.

Material And Methods: The experimental group consisted of rape victims receiving psychiatric treatment: non-violent victimization (n=125).

[Forensic implications of rape].

Introduction: Rape is a sexual act of violence in which physical strength is used. Criminal law imposes strict punishments for such crimes as rape. Psycho-pathologically, rape is among the gravest of crimes, often associated with extremely deviated behavior.

Depersonalization in Balkan endemic nephropathy.

Unlabelled: Aim of the study was to confirm depersonalization/derealization in patients with Balkan endemic nephropathy in comparison with other patients on dialysis in Bosnia and Herzegovina within the period 01.01.2000 -31-12-2006.

[Forensic evaluation of persons with destructive behavior in the postwar Bosnia and Hertzegovina].

Background/aim: Different persons show forensic differences related to aggressive behavior in criminal and violation acts. The aim of this study was to forensicly analyze the influence of socio-dynamic conditions and stress in testing the forensic hypothesis of hetero-destruction, and analysis of persons with destructive behavior in Bosnia and Hertzegovina (B&H) in the period from 1996-2005.

Methods: The experimental group consisted of 125 persons who had committed a crime according to the Criminal Law of B&H and, thus were under security measures or treatment The control group consisted of 125 persons who had committed a violation.

[Thanatophobia in the patients on dialysis].

Background/aim: Thanatophobia is an exaggerated, specific, structured fear of death. It appears in childhood and continues to grow over the years, and in the old age it is accompanied with nosophobia and other mental disorders. The aim of this study was to analyze thanatophobia in dialysed patients which was in the direct connection with a basic disorder, and the influence of this disorder on functioning and the quality of life of the patients on dialysis.