Metabolism-mediated interaction potential of standardized extract of through rat and human liver microsomes.

Objective: is used for treatment of several diseases in Indian system of medicine. In the present study, the inhibition potential of extracts and its constituent tinosporaside to cause herb-drug interactions through rat and human liver cytochrome enzymes was evaluated.

Materials And Methods: Bioactive compound was quantified through reverse phase high-performance liquid chromatography, to standardize the plant extracts and interaction potential of standardized extract.

Botanicals as medicinal food and their effects on drug metabolizing enzymes.

Botanicals fall under different regulations in different countries and are mostly consumed without the consultation of the healthcare professional. Over the last decade, utilization of herbal therapies has been extensively documented. The findings indicate the possibility of potential herb-drug interactions due to the concomitant administration of herbal extracts and prescription/over-the-counter drugs.