Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America.

Background & Aims: Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (eg, COVID-19). This study aimed to investigate the association of genetic ancestry and race with acute-on-chronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure, and high risk of short-term death.

Methods: This prospective cohort study analyzed a comprehensive set of data, including genetic ancestry and race among several others, in 1274 patients with acutely decompensated cirrhosis who were nonelectively admitted to 44 hospitals from 7 Latin American countries.

Impact of the COVID-19 pandemic in the time to endoscopy in patients with upper gastrointestinal bleedin.

Introduction: During the COVID-19 pandemic, endoscopic procedures are associated with a high risk of SARS-CoV-2 infection. However, in cases of upper gastrointestinal bleeding (UGIB), priority should be given to an early endoscopy.

Objective: The main objective was to compare the time since arrival at the hospital and the performance of the endoscopy between both groups.

Closure of colonic deep mural injury and perforation with endoclips.

Introduction: colorectal perforations are one of the most feared complications after performing an endoscopic resection. The use of endoclips is considered for the management of these complications.

Objectives: to evaluate the efficacy and safety of the use of endoclips in the management of perforations and deep mural injuries that occur after an endoscopic colorectal resection.

[Adherence to institutional clinical practice guideline on managing upper gastrointestinal bleeding, in a hospital in Lima - Peru].

Introduction: In 2018, the Clinical Practice Guideline (CPG) for the Evaluation and Management of upper gastrointestinal bleeding (UGB) was published by the Social Security of Peru (EsSalud). It provides evidence-based statements to optimize the management of these patients.

Objective: To evaluate the adherence to the statements of the CPG at the Edgardo Rebagliati Martins National Hospital (HNERM) of EsSalud (Lima, Peru).

[Clinical profile and results of acute pancreatitis in the Intensive and Intermediate Care Unit of a general hospital].

Unlabelled: Acute pancreatitis (AP) is an acute inflammatory process of the pancreas that, according to the 2012 Atlanta classification, can be mild, moderate or severe.

Objective: Describe the epidemiological, clinical, therapeutic and outcomes of patients with AP admitted to the intensive care and intermediate care unit of a general hospital and compare them with those described in the national and international literature.

Materials And Methods: Observational study of patients with AP treated over a period of 3 years.

[Safety and efficacy of the use of self-expanding metal stents in the management ofunresectable malignant biliary stenosis].

Background: In recent years there has been an increase in the use of self-expanding metallic stents (SEMS) in patients with unresectable malignant stenosis of the bile duct. However, in Peru there are no reports on the safety and efficacy of this procedure.

Objective: To evaluate the safety and efficacy of the use of SEMS in the palliative management of malignant stenosis of the bile duct.

[Peruvian experience in the treatment of chronic hepatites C with the new direct acting antiviral drugs].

Objective: The ideal therapy for chronic hepatitis C is the use of direct acting antivirals (DAA). In Peru there is no data in this aspect, in that sense it is necessary to report real life experience with these drugs.

Material And Methods: A digital survey was sent through e-mail to hepatologists, and the data of four is considered in this study.

[Large balloon dilation for removal of choledocholithiasis difficult to extract: clinical experience].

Objective: The aim of this study was to report the initial experience of the combined use of biliary sphincterotomy plus balloon dilatation of the papilla for management of large stones.

Materials And Methods: Design: Retrospective, descriptive. This study included 18 patients in whom a hydrostatic dilatation of the papilla with large balloons was performed between June 2012 and April 2014.

[Prevalence of Helicobacter pylori in symptomatic outpatients in Red Rebagliati (EsSalud) from 2010 to 2013, Lima, Peru].

Objective: To determine the prevalence of Helicobacter pylori in symptomatic outpatients in Red Rebagliati (EsSalud) from 2010 to 2013.

Material And Methods: An observational, transversal and analytical study. Records of outpatients with diagnostic 13C-urea breath test of Helicobacter pylori in the period 2010-2013 were reviewed.

An update on the management of hepatitis C: guidelines for protease inhibitor-based triple therapy from the Latin American Association for the Study of the Liver.

Hepatitis C is a common cause of end-stage liver disease, and the main indication for liver transplantation in Latin America. Treatment of hepatitis C infected patients improves important long-term outcomes as mortality. Sustained viral response is reached in near 50% of patients with the previous management based in pegylated interferon and ribavirin.

The burden of hepatic encephalopathy in Latin America.

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome characterized by changes in cognitive function, behavior, and personality, as well as by transient neurological symptoms and electroencephalographic changes, which occur in the context of acute or chronic liver failure. Cirrhosis is the main disease associated to HE, and it is known that its incidence is increasing worldwide. As a cause of mortality, cirrhosis is ranked 14 worldwide, but 10 in developed countries.

Indications for treatment in chronic HCV infection.

HCV Infection is a global burden disease and it is related to the development of progressive liver fibrosis, cirrhosis and hepatocellular carcinoma. At least 80% of the persons that have an acute infection evolve to chronicity. This event affects the patient and their contacts for the risk of acquiring the infection.

[Epidemiology of hepatitis C virus in Peru and Latin America].

Hepatitis C infection is a global burden disease. Its relationship to chronic hepatitis, cirrhosis and hepatocellular carcinoma has been demonstrated, and at the current moment in USA and Europe is one of the major causes for liver transplantation. In Latin America, seroprevalence for HCV is between 1-2%.

[Clinical - Epidemiological characteristics of the Hepatocellular Carcinoma and treatment in the departament of digestive system diseases of the National Hospital "Eduardo Rebagliatti Martins" (HNERM) - ESSALUD].

Unlabelled: Hepatocellular carcinoma (CHC) is one of the leading causes of worldwide cancer mortality. The aim of this study is to describe the clinical and epidemiological characteristics, as well as treatment prescribed in patients with this diagnosis.

Methods: Longitudinal and prospective study that included patients with diagnosis of CHC in the Department of Digestive System at the HNERM-EsSalud between august 2007 and august 2008.

[SUPEROXID EXAGERATED PRODUCTION BY NEUTROPHILS OF PATIENTS WITH ACUTE ALCOHOLIC HEPATITIS: THERAPEUTIC IMPLICATIONS].

Alcoholic hepatitis represents the most severe form of alcoholic liver disease Recent research points to an exaggerated inflammatory response, mediated by neutrophils,as the basic mechanism of liver damage. This entity has a distinctive clinical picture and a characteristic histopathology and a poor outcome.Recent investigation reveals a complex network of intracellular and intercellular communication signals involving hepatocytes, endothelial cells, monocytes, lymphocytes, neutrophils,Ito and Kupffer cells, leading to massive migration of neutrophils from blood to liver.