Publications by authors named "Milad Taouk"
Objectives: We wished to assess time to protection from HIV-1 infection following oral tenofovir disoproxil and emtricitabine (TDF/FTC) as preexposure prophylaxis (PrEP), using ex-vivo rectal tissue infections and drug concentration measures in blood and rectal tissue.
Design/methods: Participants from the ANRS PREVENIR study (NCT03113123) were offered this sub-study after a 14-day wash-out. We used an ex-vivo model to evaluate rectal tissue HIV-1 susceptibility before and after PrEP, 2 h after two pills or 7 days of a daily pill of TDF/FTC.
Article Synopsis
- Monkeypox is a zoonotic disease originally from Africa that recently saw a global outbreak starting in April 2022, with limited understanding of its transmission.
- This observational study analyzed anal symptoms in 65 men diagnosed with monkeypox at a proctology unit in Paris during mid-2022, focusing on the association with sexually transmitted infections.
- Key findings revealed that a high percentage of cases involved sexual transmission, primarily among men who have sex with men, with common symptoms being painful anal and perianal ulcerations, and most patients experienced complete symptom resolution within 12 days.
Article Synopsis
- - The study aimed to evaluate how often severe bleeding occurs after proctological surgery and to identify risk factors, especially in the context of guidelines for anticoagulant treatment.
- - Out of 8,890 patients, only 0.7% required a hemostatic procedure, with a higher risk after hemorrhoidal surgeries, particularly the Milligan-Morgan procedure; blood transfusion was rare (0.1%).
- - Findings indicated that the use of anticoagulants and platelet inhibitors, when managed according to recommendations, did not increase bleeding risk; surprisingly, active smokers had a lower risk of severe bleeding compared to non-smokers.
Purpose: Anal fistula is a common condition in proctology, usually requiring surgical treatment. Few risk factors have been clearly identified based on solid evidence. Our research objective was to determine whether history of anal surgery was a risk factor for subsequent anal fistula.
View Article and Find Full Text PDFObjectives: In the ANRS IPERGAY pre-exposure prophylaxis (PrEP) trial, a single dose of tenofovir disoproxil fumarate and emtricitabine was taken orally 2-24 h before sexual intercourse. A sub-study was conducted to assess the pharmacokinetics of tenofovir and emtricitabine in blood, saliva and rectal tissue following this initial oral intake.
Methods: Plasma, PBMC, saliva and rectal tissue sampling was performed over 24 h in 12 seronegative men before enrolment in the ANRS IPERGAY trial, following a single dose of 600 mg tenofovir disoproxil fumarate/400 mg emtricitabine.
Purpose: Studying anal cytology to detect intraepithelial neoplasia has been demonstrated to be useful in highly selected populations. This study was designed to determine the frequency of abnormal smears in a wide sample of patients consulting for anorectal symptoms.
Methods: An anal smear was proposed during each consultation during a three-month period.
Purpose: This prospective study was designed to describe a typical attack of proctalgia fugax.
Methods: Patients were recruited from May 2003 to June 2004. Whatever the reason for consultation, they were systematically asked: "Do you ever suffer intermittent and recurring anorectal pain lasting for at least three seconds?" If the answer was yes, they were interviewed with a questionnaire and had a proctologic examination.
Purpose: This prospective study evaluated the efficacy and safety of local formalin application in chronic refractory radiation-induced hemorrhagic proctitis.
Methods: All patients were treated under anesthesia by direct application of 4 percent formalin to the affected rectal areas.
Results: The study included 33 patients (17 women) and was conducted between January 1994 and December 2001.