Publications by authors named "Milad Noei"
Natural compounds in the fight against biofilms: a review of antibiofilm strategies.
Front Pharmacol
November 2024
Article Synopsis
- - The text discusses the significance of a pathogen known for forming resilient biofilms and its antibiotic resistance, emphasizing that these biofilms help bacteria survive against immune responses and treatment.
- - Natural compounds (NCs) like curcumin and thymol show promise in disrupting biofilms through various mechanisms, including direct killing, hindering bacterial communication, and affecting gene expression linked to biofilm formation.
- - Despite their potential, challenges like low solubility and bioavailability hinder effective clinical use, prompting researchers to explore nanotechnology and innovative drug delivery methods to enhance the efficacy of these NCs.
biofilm is a community of bacteria that adhere to live or non-living surfaces and are encapsulated by an extracellular polymeric substance. Unlike individual planktonic cells, biofilms possess a notable inherent resistance to sanitizers and antibiotics. Overcoming this resistance is a substantial barrier in the medical and food industries.
View Article and Find Full Text PDFChronic rhinosinusitis (CRS) is a pathological condition characterized by persistent inflammation in the upper respiratory tract and paranasal sinuses. The epithelium serves as the first line of defense against potential threats and protects the nasal mucosa. The fundamental mechanical barrier is formed by the cell-cell contact and mucociliary clearance (MCC) systems.
View Article and Find Full Text PDFArticle Synopsis
- * Combining sublethal concentrations of ciprofloxacin with phage therapy can enhance phage progeny production, shorten lytic cycles, and significantly lower bacterial levels, particularly in biofilms, indicating potential for dual-action treatment strategies.
- * Research highlights the importance of timing in therapy, suggesting that administering phages before antibiotics maximizes effectiveness and reduces the likelihood of resistance development in both bacteria and phages, though further studies are needed to understand these interactions comprehensively.