Publications by authors named "Milad Kashi"
Infertility can harm a patient in physical, psychological, spiritual, and medical ways. This illness is unusual because it affects the patient's companion and the patient individually. Infertility is a multifactorial disease, and various etiological factors like infection are known to develop this disorder.
View Article and Find Full Text PDFNatural compounds in the fight against biofilms: a review of antibiofilm strategies.
Front Pharmacol
November 2024
Article Synopsis
- - The text discusses the significance of a pathogen known for forming resilient biofilms and its antibiotic resistance, emphasizing that these biofilms help bacteria survive against immune responses and treatment.
- - Natural compounds (NCs) like curcumin and thymol show promise in disrupting biofilms through various mechanisms, including direct killing, hindering bacterial communication, and affecting gene expression linked to biofilm formation.
- - Despite their potential, challenges like low solubility and bioavailability hinder effective clinical use, prompting researchers to explore nanotechnology and innovative drug delivery methods to enhance the efficacy of these NCs.
Article Synopsis
- Carbapenem-resistant (CR) Gram-negative bacteria have emerged as a major public health issue, with their prevalence growing over the past decade due to various resistance mechanisms.
- Genetic changes and factors like biofilms contribute to this resistance, prompting scientists to explore new strategies to combat these bacteria.
- Promising alternatives include using bacteriophages, natural products, and nanoparticles, which can not only inhibit CR bacteria but also enhance the effectiveness of traditional antibiotics while reducing side effects.