Optimized Production of Re-HYNIC-Bombesin: New Therapeutic Agent for GRPR Targeting.

Purpose: One of the most interesting methods to deliver therapeutic doses of ionizing radiation to tumor sites is radiolabeled compounds. Bombesin peptide binds to gastrin-releasing peptide receptors (GRPRs) with great affinity. Through its appropriate physical characteristics and accessibility as the W/Re generator, Re can be effectively used to develop a therapeutic radio complex.

Estimation of Human Absorbed Dose of Re-Hynic-Bombesin Based on Biodistribution Data in Rats.

Background: HYNIC-Bombesin (BBN) is a potential peptide for targeted radionuclide therapy in gastrin-releasing peptide receptor (GRPr)-positive malignancies. The Re-HYNICBBN is a promising radiopharmaceutical for use in prostate cancer therapy.

Objective: The aim of this study was to estimate the absorbed dose due to Re-HYNIC-BBN radio-complex in human organs based on bio-distribution data of rats.