Incorporating Time Delays in the Mathematical Modelling of the Human Immune Response in Viral Infections.

Mathematical modelling helps to describe the functional and causal relationships between objects in the physical world. The complexity of these models increases as more components and variables are added to maintain and observe. Differential equations are regularly used in these models, as they are able to display the interactions between several variables and describe non-linear behaviour.

The impact of a telemedicine monitoring system on positive airway pressure adherence in patients with obstructive sleep apnea: a randomized controlled trial.

Study Objectives: First-line therapy for patients with moderate to severe obstructive sleep apnea (OSA) is positive airway pressure (PAP). Although PAP is a highly efficacious treatment, adherence to PAP is still a substantial clinical problem. The objective of this study was to determine whether PAP adherence can be improved with a telemedicine monitoring system.

Telehealth-based framework for supporting the treatment of obstructive sleep apnea.

We describe an application of a computer-based system and telehealth approach for support of the continuous positive airway pressure (CPAP) treatment for obstructive sleep apnea (OSA). A conceptual framework is introduced that has four major components: patients' education and communication, measurement of patients' adherence, CPAP unit test, and CPAP treatment evaluation. The measurement and evaluation processes are based on a fuzzy logic approach and they use a set of predefined fuzzy rules.

Knowledge-based data analysis: first step toward the creation of clinical prediction rules using a new typicality measure.

Clinical prediction rules play an important role in medical practice. They expedite diagnosis and limit unnecessary tests. However, the rule creation process is time consuming and expensive.