Publications by authors named "Mila Daoud"
Article Synopsis
- cIAPs are proteins that play a crucial role in regulating TNF signaling by modifying RIPK1, and mutations in cIAP1/2 lead to severe embryonic development issues in mice due to apoptosis.
- While a modified version of RIPK1 can rescue embryonic development, its absence in cIAP1/2 mice results in inflammation and early death after weaning.
- The study reveals that cIAPs also control TNFR1-mediated toxicity independently of RIPK1 and RIPK3, providing new insights into TNF signaling and creating a mouse model to help evaluate treatments involving TNF inhibitors.
Article Synopsis
- Elevated levels of XIAP (X-linked inhibitor of apoptosis protein) are linked to malignant melanoma, helping the cancer resist cell death and promoting its progression.
- XIAP also plays a role in inflammation by facilitating neutrophil infiltration into tumors, which is crucial for melanoma growth.
- Targeting the XIAP-RIPK2-TAB1 pathway or reducing neutrophils can decrease melanoma growth, suggesting that XIAP could be a new strategy for cancer treatment.
Tumor immune escape limits durable responses to T cell therapy. Here, we examined how regulation and function of gene products that provide the target epitopes for CD8 T cell anti-tumor immunity influence therapeutic efficacy and resistance. We used a CRISPR-Cas9-based method (CRISPitope) in syngeneic melanoma models to fuse the same model CD8 T cell epitope to the C-termini of different endogenous gene products.
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