Publications by authors named "Miku Wada"
Article Synopsis
- SETD8 is a histone methyltransferase linked to endometrial cancer, influencing cell proliferation and apoptosis by modifying histone H4 at lysine 20 and affecting the p53 signaling pathway.
- The study found that SETD8 expression is significantly higher in endometrial cancer tissues and that reducing SETD8 through siRNAs or inhibitors suppresses cancer cell growth and encourages cell death.
- Key genes related to apoptosis, including KIAA1324 and TP73, were identified as being regulated by SETD8, indicating their importance in cancer progression and prognosis.
The histone methyltransferase SETD8, which methylates the lysine 20 of histone H4 (H4K20), is reportedly involved in human carcinogenesis along with nonhistone proteins such as p53. However, its expression profiles and functions in the context of high-grade serous ovarian carcinoma (HGSOC) are still unknown. The purpose of this study was to investigate the role of SETD8 in HGSOC.
View Article and Find Full Text PDFArticle Synopsis
- Dysfunction of histone methylation, particularly involving the enzyme SMYD2, is linked to cancer progression, and this study focuses on its role in high-grade serous ovarian carcinomas (HGSOCs).
- Researchers found that SMYD2 is significantly overexpressed in HGSOC tissues and demonstrated that inhibiting SMYD2 led to reduced cell growth and increased apoptosis in HGSOC cells.
- Additionally, the selective SMYD2 inhibitor LLY-507 showed potential as a standalone treatment and in combination with the PARP inhibitor olaparib, indicating a promising therapeutic strategy for patients with HGSOC.