Publications by authors named "Miku Serizawa"
J Control Release
September 2024
Article Synopsis
- Lipid nanoparticles (LNPs) are being explored as carriers for delivering nucleic acid drugs, primarily focusing on their distribution to organs beyond the liver, like the spleen and lungs, by modifying phospholipid compositions.
- This study specifically investigates how different types of phospholipids and particle sizes affect the targeting of pancreatic islets, which are crucial for diabetes treatment, using fluorescence-labeled LNPs in mice.
- Results showed that DOPC-LNPs had the highest distribution in the pancreas and pancreatic islets, especially at larger sizes (160 nm), while smaller particles were more prevalent in exocrine glands.*
