The evolutionary arch of bioenergetics from prebiotic mechanisms to the emergence of a cellular respiratory chain.

This article proposes an evolutionary trajectory for the development of biological energy producing systems. Six main stages of energy producing system evolution are described, from early evolutionary pyrite-pulled mechanism through the Last Universal Common Ancestor (LUCA) to contemporary systems. We define the Last Pure Chemical Entity (LPCE) as the last completely non-enzymatic entity.

Lactate in exhaled breath condensate and its correlation to cancer: challenges, promises and a call for data.

Owing to its connection to cancer metabolism, lactate is a compound that has been a focus of interest in field of cancer biochemistry for more than a century. Exhaled breath volatile organic compounds (VOCs) and condensate analyses can identify and monitor volatile and non-VOCs, respectively, present in exhaled breath to gain information about the health state of an individual. This work aims to take into account the possible use of breath lactate measurements in tumor diagnosis and treatment control, to discuss technical barriers to measurement, and to evaluate directions for the future improvement of this technique.

Metabolic Shades of S-D-Lactoylglutathione.

S-D-lactoylglutathione (SDL) is an intermediate of the glutathione-dependent metabolism of methylglyoxal (MGO) by glyoxalases. MGO is an electrophilic compound that is inevitably produced in conjunction with glucose breakdown and is essentially metabolized via the glyoxalase route. In the last decades, MGO metabolism and its cytotoxic effects have been under active investigation, while almost nothing is known about SDL.

Hidden biochemical fossils reveal an evolutionary trajectory for glycolysis in the prebiotic era.

Glycolysis is present in nearly all organisms alive today. This article proposes an evolutionary trajectory for the development of glycolysis in the framework of the chemoautotrophic theory for the origin of life. In the proposal, trioses and triose-phosphates were appointed to starting points.

[Hungarian psychiatric care in the light of the closure of the National Institute of Psychiatry and Neurology, and the reduction of the number of hospital beds. A decade and a half under investigation].

The "Act on the Development of the Health Care System, CXXXII/2006" ordered a general reduction in the number of hospital beds, which sensitively affected the care of psychiatric inpatients, too. In this wave of downsizing, the National Institute of Psychiatry and Neurology, an institute with the traditions of one and a half centuries, also ceased to exist. Based on statistical data, the article examined the effect of the law on inpatient and outpatient psychiatric/ addictological care.

Evolutionary Aspects of the Oxido-Reductive Network of Methylglyoxal.

In the chemoautotrophic theory for the origin of life, offered as an alternative to broth theory, the archaic reductive citric acid cycle operating without enzymes is in the center. The non-enzymatic (methyl)glyoxalase pathway has been suggested to be the anaplerotic route for the reductive citric acid cycle. In the recent years, much has been learned about methylglyoxal, but its importance in the metabolic machinery is still uncovered.

Changes in national rates of psychiatric beds and incarceration in Central Eastern Europe and Central Asia from 1990-2019: A retrospective database analysis.

Background: Numbers of psychiatric beds (general, forensic, and residential) and prison populations have been considered to be indicators of institutionalisation of people with mental illnesses. The present study aimed to assess changes of those indicators across Central Eastern Europe and Central Asia (CEECA) over the last three decades to capture how care has developed during that historical period.

Methods: We retrospectively obtained data on numbers of psychiatric beds and prison populations from 30 countries in CEECA between 1990 and 2019.

Negative trends in outpatient care of addicted patients in Hungary.

Objectives: This article investigates how the numbers of registered addict patients have changed in the last three decades in Hungary and whether the predicted HIV epidemic among intravenous drug users has occurred.

Methods: Data were collected from the Annual Reports of the National Bureau of Statistics and National Epidemiological Centre as well as from the medical records of the author.

Results: The total number of registered alcoholics decreased by about 75% during the investigated period.

[The changes of roles and their effects on the functioning of the family of alcoholics. The history of two families].

The alcohol dependence of a family member redraws familiar relationships and creates a dysfunctional network. Therefore, the relationship between the individual and the family, the interactions and processes that occur must be examined during the therapy in order to understand the behavior of an alcoholic. The observations obtained in stu - dying the role of family members in the development and maintenance of pathological alcohol use disorders provide the scientific basis for this.

Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation.

Reactive oxygen species (ROS) are produced constantly inside the cells as a consequence of nutrient catabolism. The balance between ROS production and elimination allows to maintain cell redox homeostasis and biological functions, avoiding the occurrence of oxidative distress causing irreversible oxidative damages. A fundamental player in this fine balance is reduced glutathione (GSH), required for the scavenging of ROS as well as of the reactive 2-oxoaldehydes methylglyoxal (MGO).

Does Penrose's Law apply to Hungary? Data of an extended survey and reappraisal.

Penrose described an observation in 1939, according to which an inverse relationship between the size of prison populations and the number of psychiatric beds existed. The purpose of this article was to investigate the validity of this statement for Hungary. The national data between 1989 and 2017 for 25 variables were extracted from the official reports of the Hungarian Central Statistical Office.

[The abuse and dependence of chemical agents in an evolutionary approach/From adaptation to the phenomenon of "run-away" and beyond].

A recent paradigm shift in medicine resulted in the emergence of so-called evolutionary medicine, which studies the interactions between the environment and biological phenomena in a timeline to understand diseases and develop new treatments. In the course of evolutionary discussion of chemical substance abuse, the issue was approached through five steps. The biological level helps to understand the interference and coevolution of chemical agents and biochemical mechanisms, thus demonstrating the vulnerability toward chemical agents.

[Examination of the mortality data of patients, treated by the "TÁMASZ" Addictological Out-patient Clinic in Józsefváros (in Budapest, Hungary), who deceased in 2001-2018].

The analysis of the mortality data of patients is important. Examination of data from patients treated in the Addictological Out-patient Clinic in Józsefváros and deceased between 2001 and 2018. Patients' data originated from medical records.

Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging.

Both cancer and Alzheimer's disease (AD) are emerging as metabolic diseases in which aberrant/dysregulated glucose metabolism and bioenergetics occur, and play a key role in disease progression. Interestingly, an enhancement of glucose uptake, glycolysis and pentose phosphate pathway occurs in both cancer cells and amyloid-β-resistant neurons in the early phase of AD. However, this metabolic shift has its adverse effects.

Breath profiles of children on ketogenic therapy.

Ketogenic diets (KDs) were initially introduced to clinical practices as alimentary approaches with the aim to control drug-resistant epilepsies. Over the decades, a large and growing body of research has addressed the antiseizure effect of various KDs, and worked out KD-based dietary regimens, including their acting factors and modes of action. KDs have also appeared in weight loss therapies.

Breath acetone as a potential marker in clinical practice.

In recent decades, two facts have changed the opinion of researchers about the function of acetone in humans. Firstly, it has turned out that acetone cannot be regarded as simply a waste product of metabolism, because there are several pathways in which acetone is produced or broken down. Secondly, methods have emerged making possible its detection in exhaled breath, thereby offering an attractive alternative to investigation of blood and urine samples.

Penrose's law: Methodological challenges and call for data.

The investigation of the relationship between the sizes of the mental health population and the prison population, outlined in Penrose's Law, has received renewed interest in recent decades. The problems that arise in the course of the deinstitutionalization have repeatedly drawn attention to this issue. This article presents methodological challenges to the examination of Penrose's Law and retrospectively reviews historical data from empirical studies.

[Addiction therapy. Limits, problems, perspectives].

In health care, tending is a process, which offers for the patients a continuous watching on, a control, a treatment, and the prevention of worsening of their medical status as well as the reduction of their complaints. In the article, some fundamental segments of tending in addictology are reviewed, particularly paying attention to whom, how, where and how long to take care. On the basis of literature, the author stresses whatever method is used to treat addict patients it is more beneficial to society than the avoidance of any intervention due to the negligence of the problem.

Where does plasma methylglyoxal originate from?

The elevation of plasma methylglyoxal levels in diabetic humans is widely observed, but it is unknown to what extent different sources of methylglyoxal contribute to its plasma concentration. A retrospective analysis of clinical findings has been undertaken. There is controversy about the correlation of plasma methylglyoxal concentrations with fasting or postprandial glucose levels, and the relationship with HbA1c.

[Investigation of the frequency of alcohol related problems in Józsefváros, Budapest. Data and conclusions of three surveys conducted among doctors and outpatients].

Unlabelled: The role of permanent alcohol consumption in the development of diseases is well-known.

Aims: To study the occurrence of alcohol related problems among patients of a municipal pulmonology out-patient clinic as well as in the family practice of three physicians. In addition, a survey was performed among physicians of a municipal health service and also among family practitioners working in the same district by investigating health problems, habits and professional careers of physicians, and their addictive problems, their attitude toward addict patients and their opinion upon chemical dependency.