Publications by authors named "Mikko S Mattila"
Article Synopsis
- The study aimed to assess the impact of an adenosine bolus compared to saline during the initial cardioplegia on patient outcomes in aortic valve replacement (AVR) surgeries.
- During the trial, 45 patients were randomized to receive either adenosine or saline, with various cardiac function metrics measured over time.
- The results indicated no significant differences in cardiac index or other secondary outcomes between the two groups, although the left ventricular stroke work index was lower in the adenosine group.
Background: We aimed to summarise the existing knowledge regarding antithrombotic medications following surgical aortic valve replacement (SAVR) using a biological valve prosthesis.
Methods: We performed a meta-analysis of studies that reported the results of using antithrombotic medication to prevent thromboembolic events after SAVR using a biological aortic valve prosthesis and recorded the outcomes 12 months after surgery. Since no randomised controlled trials were identified, observational studies were included.
Background And Objective: In this clinical trial, we evaluated if a short-acting nucleoside, adenosine, as a high-dose bolus injection with blood cardioplegia induces faster arrest and provides better myocardial performance in patients after bypass surgery for coronary artery disease.
Methods: Forty-three patients scheduled for elective or urgent coronary artery bypass grafting were prospectively recruited in two-arm 1:1 randomized parallel groups to either receive 20 mg of adenosine (in 21 patients) or saline (in 22 patients) into the aortic root during the first potassium-enriched blood cardioplegia infusion. The main outcomes of the study were ventricular myocardial performance measured with cardiac index, right ventricular stroke work index, and left ventricular stroke work index at predefined time points and time to asystole after a single bolus injection of adenosine.