Publications by authors named "Mikko Juhani Lammi"
Article Synopsis
- - The study used single-cell and spatial transcriptomics to analyze knee cartilage from 8 osteoarthritis (OA) donors and 3 non-OA controls, revealing a detailed transcriptome and identifying key cell populations involved in OA.
- - Researchers discovered 11 distinct chondrocyte populations, including 2 novel ones: the pre-inflammatory chondrocyte population (preInfC) and the inflammatory chondrocyte population (InfC), which are crucial for understanding the disease.
- - The findings suggest that specific chondrocyte populations, like InfC and preHTC, could be targeted for new OA therapies, and profiling these cells may help categorize patients for future clinical trials and personalized treatments.
Glycoproteins are involved in the development of many diseases, while the type and content of N-glycoproteins in the cartilage of osteoarthritis (OA) and Kashin-Beck disease (KBD) are still unclear. This research aims to identify N-glycoproteins in knee cartilage patients with OA and KBD compared with normal control (N) adults. The cartilage samples were collected from gender- and age-matched OA ( = 9), KBD ( = 9) patients, and N ( = 9) adults.
View Article and Find Full Text PDFIdentifying discriminative features for diagnosis of Kashin-Beck disease among adolescents.
BMC Musculoskelet Disord
September 2021
Introduction: Diagnosing Kashin-Beck disease (KBD) involves damages to multiple joints and carries variable clinical symptoms, posing great challenge to the diagnosis of KBD for clinical practitioners. However, it is still unclear which clinical features of KBD are more informative for the diagnosis of Kashin-Beck disease among adolescent.
Methods: We first manually extracted 26 possible features including clinical manifestations, and pathological changes of X-ray images from 400 KBD and 400 non-KBD adolescents.
Background: A group of differentially expressed long non-coding RNAs (lncRNAs) have been shown to play key roles in osteoarthritis (OA), although they represented only a small proportion of lncRNAs that may be biologically and physiologically relevant. Since our knowledge of regulatory functions of non-coding RNAs is still limited, it is important to gain better understanding of their relation to the pathogenesis of OA.
Methods: We performed mRNA and lncRNA microarray analysis to detect differentially expressed RNAs in chondrocytes from three OA patients compared with four healthy controls.
Thyroid hormone triiodothyronine (T) plays an important role in coordinated endochondral ossification and hypertrophic differentiation of the growth plate, while aberrant thyroid hormone function appears to be related to skeletal malformations, osteoarthritis, and Kashin-Beck disease. The T-2 toxin, present extensively in cereal grains, and one of its main metabolites, HT-2 toxin, are hypothesized to be potential factors associated with hypertrophic chondrocyte-related osteochondropathy, known as the Kashin-Beck disease. In this study, we investigated the effects of T and HT-2 toxin on human chondrocytes.
View Article and Find Full Text PDFObjective: The objective of this study is to explore the cytokines in serum, synovial fluid as potential biomarkers of Kashin-Beck disease (KBD) and to further understand the role of these cytokines in the pathogenesis of KBD.
Methods: A systematic electronic database search was performed from inception up to 15 March 2015. Meta-analysis was performed for cytokines more than one repetition in studies with available data.