GMP production of 6-[F]Fluoro-L-DOPA for PET/CT imaging by different synthetic routes: a three center experience.

Background: The radiofluorinated levodopa analogue 6-[F]F-L-DOPA (3,4-dihydroxy-6-F-L-phenylalanine) is a commonly employed radiotracer for PET/CT imaging of multiple oncological and neurological indications. An unusually large number of different radiosyntheses have been published to the point where two different Ph. Eur.