Publications by authors named "Mikkel Karl Emil Nygaard"
Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis: The Early Multiple Sclerosis Exercise Study (EMSES).
Morten Riemenschneider Lars G Hvid Steffen Ringgaard Mikkel Karl Emil Nygaard Simon Fristed Eskildsen
Mult Scler
September 2022
Background: Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, and an uninvestigated 'window of opportunity' exists early in the disease course.
Objective: To investigate the effect of early exercise on relapse rate, global brain atrophy and secondary magnetic resonance imaging (MRI) outcomes.
Article Synopsis
- A 1-year study compared individuals with multiple sclerosis (PwMS) who responded to Fampridine treatment versus those who did not, looking at various disability measures and performance tests.
- The study included tests like the timed 25-foot walk and symbol digit modalities test, finding prolonged peripheral motor conduction times in non-responders, but no significant differences in other tests.
- Central motor conduction times were linked to disability status, while cognitive performance was associated with MRI-visible brain lesions, suggesting the potential use of these measures to track progression in MS.
A cross-sectional comparison of performance, neurophysiological and MRI outcomes of responders and non-responders to fampridine treatment in multiple sclerosis - An explorative study.
Sepehr Mamoei Henrik Boye Jensen Ulrik Dalgas Inge Zijdewind Andreas Kristian Pedersen Mikkel Karl Emil Nygaard
J Clin Neurosci
December 2020
Article Synopsis
- The study aimed to compare physical and cognitive performance, neurophysiological outcomes, and MRI results between participants with Multiple Sclerosis who responded or did not respond to Fampridine treatment.
- Despite assessing 41 responders and 8 non-responders, no significant differences were found in any measured outcomes between the two groups.
- However, certain associations were noted, such as the connection between central motor conduction time (CMCT) and various performance measures, as well as the relationship between the Symbol Digit Modalities Test (SDMT) and T2-weighted MRI lesions, highlighting potential markers for disability and walking impairment.
Article Synopsis
- The study aimed to investigate the impact of 24 weeks of high-intensity progressive aerobic exercise on brain MRI measures in individuals with multiple sclerosis (MS).
- Eighty-six participants were randomly divided into an exercise group and a waitlist group; the exercise group showed improvements in cardiorespiratory fitness and a lower rate of relapses, but there was no significant change in brain volume.
- The findings suggest that while aerobic exercise doesn't protect against brain atrophy in MS, it could potentially help reduce relapse rates, indicating the need for further research into its therapeutic benefits.