Publications by authors named "Mikkel K E Nygaard"
Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis: The Early Multiple Sclerosis Exercise Study (EMSES).
Mult Scler
September 2022
Background: Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, and an uninvestigated 'window of opportunity' exists early in the disease course.
Objective: To investigate the effect of early exercise on relapse rate, global brain atrophy and secondary magnetic resonance imaging (MRI) outcomes.
Article Synopsis
- A 1-year study compared individuals with multiple sclerosis (PwMS) who responded to Fampridine treatment versus those who did not, looking at various disability measures and performance tests.
- The study included tests like the timed 25-foot walk and symbol digit modalities test, finding prolonged peripheral motor conduction times in non-responders, but no significant differences in other tests.
- Central motor conduction times were linked to disability status, while cognitive performance was associated with MRI-visible brain lesions, suggesting the potential use of these measures to track progression in MS.
Background: In multiple sclerosis (MS), pronounced neurodegeneration manifests itself as cerebral gray matter (GM) atrophy, which is associated with cognitive and physical impairments. Microstructural changes in GM estimated by diffusion kurtosis imaging (DKI) may reveal neurodegeneration that is undetectable by conventional structural MRI and thus serve as a more sensitive marker of disease progression.
Objective: The primary objective was to investigate the relationships between morphological and diffusional properties in cerebral GM and physical and cognitive performance in relapsing-remitting MS (RRMS) patients.
Breastfed infants have higher intestinal lipid absorption and neurodevelopmental outcomes compared to formula-fed infants, which may relate to a different surface layer structure of fat globules in infant formula. This study investigated if dairy-derived emulsifiers increased lipid absorption and neurodevelopment relative to soy lecithin in newborn preterm piglets. Piglets received a formula diet containing soy lecithin (SL) or whey protein concentrate enriched in extracellular vesicles (WPC-A-EV) or phospholipids (WPC-PL) for 19 days.
View Article and Find Full Text PDFArticle Synopsis
- * It involves a 48-week randomized controlled trial comparing two groups: one receiving supervised high-intense exercise alongside usual care, and another getting health education as a control, with outcomes including relapse rates and brain atrophy.
- * The research has ethical approval and aims to publish findings in peer-reviewed journals, highlighting the importance of exercise in MS management.
A cross-sectional comparison of performance, neurophysiological and MRI outcomes of responders and non-responders to fampridine treatment in multiple sclerosis - An explorative study.
J Clin Neurosci
December 2020
Article Synopsis
- The study aimed to compare physical and cognitive performance, neurophysiological outcomes, and MRI results between participants with Multiple Sclerosis who responded or did not respond to Fampridine treatment.
- Despite assessing 41 responders and 8 non-responders, no significant differences were found in any measured outcomes between the two groups.
- However, certain associations were noted, such as the connection between central motor conduction time (CMCT) and various performance measures, as well as the relationship between the Symbol Digit Modalities Test (SDMT) and T2-weighted MRI lesions, highlighting potential markers for disability and walking impairment.
Article Synopsis
- The study aimed to investigate the impact of 24 weeks of high-intensity progressive aerobic exercise on brain MRI measures in individuals with multiple sclerosis (MS).
- Eighty-six participants were randomly divided into an exercise group and a waitlist group; the exercise group showed improvements in cardiorespiratory fitness and a lower rate of relapses, but there was no significant change in brain volume.
- The findings suggest that while aerobic exercise doesn't protect against brain atrophy in MS, it could potentially help reduce relapse rates, indicating the need for further research into its therapeutic benefits.