Synopsis of recent research by authors named "Mikk Tooming"
- Mikk Tooming's recent research primarily focuses on the genetic aspects of cancer, specifically analyzing the prevalence and molecular characteristics of various inherited cancer syndromes, including CHEK2-related breast cancer and Lynch syndrome colorectal cancer in the Estonian population.
- His studies reveal that individuals with biallelic CHEK2 germline pathogenic variants exhibit a heterogeneous cancer phenotype, with a notable increase in multiple breast cancer occurrences, while also uncovering significant insights into the prevalence and genetic variants of Lynch syndrome.
- Additionally, Tooming's work emphasizes the urgent need for incorporating population-based genetic findings into clinical preventive strategies, as demonstrated by his pilot study that assessed the genetic predisposition to breast cancer among participants of an Estonian biobank.
