Blunt circulatory response to exercise in coronary high-risk subjects among apparently healthy Japanese.

Background: Endothelial dysfunction leads to atherosclerosis and the hypothesis of the present study was that the systemic circulatory response during exercise would be a manifestation of endothelial dysfunction.

Methods And Results: The circulatory response to exercise of 1,214 apparently healthy people (946 men, mean age 51.2 +/- 10.

Higher C-reactive protein concentration and white blood cell count in subjects with more coronary risk factors and/or lower physical fitness among apparently healthy Japanese.

Of 2,722 people (1.876 men, mean age: 51.3+/-10.