Publications by authors named "Mikio Shirota"
Article Synopsis
- - Anamorelin is an oral drug designed to treat cancer cachexia, a condition often seen in cancer patients, and it interacts with the liver enzyme CYP3A4, which can lead to drug-drug interactions.
- - The study developed a high-performance liquid chromatography-ultraviolet (HPLC-UV) method to measure anamorelin levels in human plasma, focusing on sample preparation and accurate separation using specific chemical conditions.
- - The method showed a strong calibration curve and good precision and accuracy, suggesting it could be effectively used in clinical settings to monitor anamorelin concentration.
Article Synopsis
- Olaparib is a drug used for treating ovarian cancer, specifically as maintenance therapy after chemotherapy, but it can cause anemia in some patients due to its varying effects on drug concentration in the body.
- A new assay using high-performance liquid chromatography with ultraviolet light (HPLC-UV) has been developed to monitor olaparib concentrations in patients, ensuring effective drug dosage and safety.
- The HPLC-UV method demonstrated high accuracy and reliability, making it a promising tool for clinical use in managing olaparib therapy for ovarian cancer patients.
Article Synopsis
- * A new method using high-performance liquid chromatography with ultraviolet detection (HPLC-UV) was developed to accurately measure sotorasib levels in human plasma, showing strong reliability and precision.
- * This method was used to measure sotorasib concentrations in a patient with KRAS G12C-mutated lung cancer, and it is expected to aid in evaluating the drug's safety and effectiveness in larger groups of patients.
Article Synopsis
- * The study developed a high-performance liquid chromatography-ultraviolet (HPLC-UV) method to accurately measure cabozantinib concentration in human plasma, achieving a linear calibration curve and high recovery rates.
- * This HPLC-UV method is efficient (9 minutes per measurement) and simple enough to be used in clinical settings for effective patient monitoring.
Article Synopsis
- Interruptions during carboplatin infusion in chemotherapy patients can negatively impact treatment effectiveness and quality of life.
- The study focused on identifying the causes of these interruptions by analyzing filters and catheter surfaces with advanced imaging techniques.
- Results indicated that increased pushing force was needed after dripping failures, suggesting drug adherence on catheter surfaces could hinder carboplatin delivery, highlighting the importance of maintaining catheter integrity during treatment.
Article Synopsis
- - The study aimed to investigate how prolonged intravenous acetaminophen infusion affects blood pressure in intensive care patients.
- - Researchers compared two groups: one received a short 15-minute infusion, while the other had an infusion lasting longer than 15 minutes, using statistical methods to account for differences.
- - Results showed that the short infusion did not change diastolic blood pressure, but the prolonged infusion led to a significant decrease in blood pressure after 30 and 60 minutes, indicating that longer acetaminophen infusions do not mitigate blood pressure drops.
The aim of this study was to determine the proportion of near-miss dispensing errors in hospital pharmacies in Japan. A prospective multi-center observational study was conducted between December 2018 and March 2019. The primary objective was to determine the proportion of near-miss dispensing errors in hospital pharmacy departments.
View Article and Find Full Text PDFOutpatient cancer chemotherapy is becoming increasingly widely adopted. It is, therefore, essential to strengthen the collaboration between hospital and community pharmacists. Although there have been several reports on the collaboration between these two health care providers in the provision of outpatient cancer chemotherapy, there have been no reports on the usefulness of the tools provided by hospital pharmacists to their community counterparts.
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