Publications by authors named "Mikiko I Kakegawa"
Background: The advancement of cancer genomics has allowed for multiplex gene assays using next-generation sequencing (NGS) to be practically implemented, however, a clinical practice system remains to be established.
Objective: We evaluated the feasibility of clinical sequencing using NGS-based multiplex gene assays between cooperating medical institutions in patients with advanced cancers.
Methods: In this observational study, DNA and RNA samples prepared from existing tumor tissues were subjected to comprehensive genomic profiling using targeted sequencing.
Article Synopsis
- The study focuses on the effectiveness of chemoradiotherapy (CRT) for patients with unresectable locally advanced non-small cell lung cancer (NSCLC) before the approval of durvalumab, an immune checkpoint inhibitor (ICI).
- Out of 108 patients analyzed, a high completion rate of CRT was noted, with a significant number developing radiation pneumonitis.
- Results showed a 64% overall response rate and a 63% two-year survival rate, indicating that the introduction of ICIs after relapse significantly improved survival outcomes.