Publications by authors named "Miki Takenaka Sato"
Purpose: The blood concentrations of some tyrosine kinase inhibitors are known to decrease with long-term administration. We evaluated the variability in the serum concentrations of sunitinib and its metabolites in patients receiving long-term sunitinib treatment.
Methods: This study prospectively recruited patients who received sunitinib for metastatic renal cell carcinoma at the Showa University Hospital between March 2020 and January 2022.
Rationale: Neovascular age-related macular degeneration (AMD) is a progressive eye disease characterized by choroidal neovascularization (CNV) and is a leading cause of vision loss and disability worldwide. Although intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is an effective treatment option that helps to prevent vision loss or to improve visual acuity in people with neovascular AMD, treatment imposes a significant financial burden on patients and healthcare systems. A biosimilar is a biological product that has been developed to be nearly identical to a previously approved biological product.
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- The study investigates how effective alternative antibiotics are compared to carbapenems for treating complicated urinary tract infections (cUTIs) caused by resistant bacteria.
- Researchers conducted a systematic review and meta-analysis, examining randomized controlled trials that focused on adult patients with these infections.
- The findings suggest that there is no significant difference in the effectiveness of alternative antibiotics versus carbapenems, indicating similar clinical outcomes for treating cUTIs caused by resistant uropathogens.
Article Synopsis
- Chemotherapy-induced peripheral neuropathy (CIPN) is a common and limiting side effect of chemotherapy, and while many trials have investigated drugs for its prevention or treatment, previous reviews haven't proven their effectiveness.
- The article outlines a protocol for a systematic review and network meta-analysis (NMA) aimed at assessing the efficacy and safety of various drugs, including vitamins and analgesics, in preventing and treating CIPN.
- The research will involve a comprehensive literature search for relevant studies and will utilize statistical methods to analyze the effectiveness of treatments, with findings expected to be published in a peer-reviewed journal.
Background: The association between the combination of platelet count and neutrophil-lymphocyte ratio (COP-NLR) at the time of adverse events during sunitinib treatment and prognosis is unclear, and prognostic models combining the prognostic factors of sunitinib have not been well studied. Thus, we developed a prognostic model that includes the COP-NLR to predict the prognosis of patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib.
Methods: We performed a retrospective cohort study of 102 patients treated with sunitinib for mRCC between 2008 and 2020 in three hospitals associated with Showa University, Japan.