Publications by authors named "Miki Suemura"
Article Synopsis
- Canine lymphoma is the most prevalent form of cancer in dogs and has a high mortality rate, prompting research into potential treatments.
- The inhibitor dynasore was found to significantly reduce the viability of various canine lymphoma cell lines while inducing apoptosis specifically in cancerous cells, but not in healthy cells.
- The study suggests that dynasore could be an effective new treatment option for canine lymphoma by triggering a DNA damage response in cancer cells.
The endocytosis inhibitor dynasore induces a DNA damage response pathway that can be manipulated for enhanced apoptosis.
Biochem Biophys Res Commun
February 2023
Article Synopsis
- Endocytosis is crucial for cancer growth and spread, and its inhibitors can reduce cancer cell proliferation and migration.
- The endocytosis inhibitor dynasore was found to decrease cell viability in various cancer types, particularly hematopoietic cancers, by inducing apoptosis and delaying cell cycle progression.
- Dynasore activates the ATR-Chk1 DNA damage response, indicating potential DNA replication stress, and combining it with an ATR inhibitor enhances the effects, highlighting a possible new approach for cancer treatment.