Publications by authors named "Miki Onoue"
Amphiregulin-producing T2 cells facilitate esophageal fibrosis of eosinophilic esophagitis.
J Allergy Clin Immunol Glob
August 2024
Article Synopsis
- - Massive eosinophil infiltration in eosinophilic esophagitis (EoE) can lead to esophageal fibrosis, but the specific mechanisms are not fully understood.
- - Researchers created a mouse model of EoE to study immune cell behavior and found increased T2 cells producing amphiregulin and IL-5 in fibrotic areas after exposure to house dust mites.
- - The study showed that higher levels of amphiregulin-producing CD4 T cells correlate with greater fibrosis in EoE patients, suggesting that targeting amphiregulin could be a new therapeutic strategy.
Article Synopsis
- Uncontrolled type 2 immunity by Th2 cells leads to severe allergic diseases, but the exact role of CD4 T cell interactions in this process is not fully understood.
- Researchers found a specific group of Th2 cells that produce granzyme A and B early in their development, which activates pathways that boost the production of allergic response markers IL-5 and IL-13.
- Targeting the pathway involving USP7, STAT3, granzymes, and PAR-1 may offer new treatment options for difficult-to-treat allergic conditions, as evidenced by findings in nasal polyps from patients with chronic rhinosinusitis.
Allergic diseases arise from a complex interplay between immune system and environmental factors. A link between the pathogenesis of allergic diseases and type 2 immune responses has become evident, with conventional and pathogenic type 2 helper T (Th2) cells involved in both. Recently, there has been a significant development in therapeutic agents for allergic diseases: IL-5 and IL-5 receptor antagonists, Janus kinase (JAK) inhibitors, and sublingual immunotherapy (SLIT).
View Article and Find Full Text PDFAllergic conjunctivitis is a chronic inflammatory disease that is characterized by severe itch in the conjunctiva, but how neuro-immune interactions shape the pathogenesis of severe itch remains unclear. We identified a subset of memory-type pathogenic Th2 cells that preferentially expressed Il1rl1-encoding ST2 and Calca-encoding calcitonin-gene-related peptide (CGRP) in the inflammatory conjunctiva using a single-cell analysis. The IL-33-ST2 axis in memory Th2 cells controlled the axonal elongation of the peripheral sensory C-fiber and the induction of severe itch.
View Article and Find Full Text PDFTo clarify the early alterations of gene expression using a mouse model of glaucoma filtration surgery, we carried out microarray expression analysis. Using BALB/c mice, a filtration surgery model was made by incision of the limbal conjunctiva, followed by the insertion of a 33G needle tip into the anterior chamber, and 11-0 nylon sutures. Subgroups of mice were treated intraoperatively with 0.
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