Publications by authors named "Miki Hagimoto-Akasaka"
This study evaluated the impact of the coronavirus disease 2019 (COVID-19) pandemic on the occurrence of maternal primary cytomegalovirus (CMV) infection in Japan. We performed a nested case-control study using data from maternal CMV antibody screening under the Cytomegalovirus in Mother and infant-engaged Virus serology (CMieV) program in Mie, Japan. Pregnant women with negative IgG antibodies at ≤20 weeks of gestation who were retested at ≥28 weeks were enrolled.
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- Cytomegalovirus (CMV) is linked to congenital infections, and this study aimed to validate a new IgM titer cutoff for detecting primary infections in pregnant women.
- Over two time periods (2013-2017 and 2017-2019), researchers screened a total of nearly 32,000 women for CMV antibodies, with findings showing similar rates of IgM positives and congenital CMV cases across the two periods.
- The revised IgM cutoff effectively enhances screening for primary CMV infections in mothers and newborns, though more research is needed on other testing methods beyond the Denka assay.