Publications by authors named "Mikhina Ekaterina"
Article Synopsis
- Ribavirin and its modified versions were found to have a significant effect on inhibiting the growth of cancer cells, particularly leukemia cells.
- Researchers synthesized several derivatives of ribavirin, specifically targeting their structural positions to evaluate their antiproliferative and antimicrobial properties, showing that some were effective against both Gram-positive and Gram-negative bacteria.
- The most promising derivative, n-decyloxymethyl, was shown to kill leukemia cells at low doses by disrupting cell cycle progression and potentially inhibiting critical cellular processes involved in cancer growth.
Background: A number of studies demonstrate the efficacy of ribavirin against various cancer types in and models. However, ribavirin induces the development of multiple side effects, suggesting a high demand for ribavirin analogues with improved therapeutic indexes.
Objective: This study was focused on the analysis of ribavirin, its aglycon 1,2,4-triazole-3-carboxamide, and several of its derivatives activities in blood cancer cells .