[A case of severe hyperparathyroidism in clinical practice. Case report].

Disorders of the mineral balance often determine the symptoms, the severity of the course and the prognosis of many diseases. Primary hyperparathyroidism (PHPT) is a common endocrine disease caused by increased secretion of parathyroid hormone as a result of primary damage to the parathyroid glands. Diagnosis of PHPT is often difficult.

A Randomized, Phase III Trial to Evaluate Rucaparib Monotherapy as Maintenance Treatment in Patients With Newly Diagnosed Ovarian Cancer (ATHENA-MONO/GOG-3020/ENGOT-ov45).

Purpose: ATHENA (ClinicalTrials.gov identifier: NCT03522246) was designed to evaluate rucaparib first-line maintenance treatment in a broad patient population, including those without or (BRCA) mutations or other evidence of homologous recombination deficiency (HRD), or high-risk clinical characteristics such as residual disease. We report the results from the ATHENA-MONO comparison of rucaparib versus placebo.

Multi-Enzymatic Cascades in the Synthesis of Modified Nucleosides: Comparison of the Thermophilic and Mesophilic Pathways.

A comparative study of the possibilities of using ribokinase → phosphopentomutase → nucleoside phosphorylase cascades in the synthesis of modified nucleosides was carried out. Recombinant phosphopentomutase from HB27 was obtained for the first time: a strain producing a soluble form of the enzyme was created, and a method for its isolation and chromatographic purification was developed. It was shown that cascade syntheses of modified nucleosides can be carried out both by the mesophilic and thermophilic routes from D-pentoses: ribose, 2-deoxyribose, arabinose, xylose, and 2-deoxy-2-fluoroarabinose.

The comparative analysis of the properties and structures of purine nucleoside phosphorylases from thermophilic bacterium HB27.

Two recombinant purine nucleoside phosphorylases from thermophilic bacterium HB27 encoded by genes TT_C1070 (PNPI) and TT_C0194 (PNPII) were purified and characterized. The comparative analysis of their sequences, molecular weight, enzymes specificity and kinetics of the catalyzed reaction were realized. As a result, it was determined that the PNPI is specific to guanosine while the PNPII to adenosine.

[Clinical case of IgG4-related disease in a patient with Burkitt lymphoma].

The article provides a case of primary diagnosis of IgG4-related disease in a patient with Burkitt lymphoma.

Second-line lenvatinib in patients with recurrent endometrial cancer.

Objective: This study assessed the efficacy of lenvatinib, a multitargeted tyrosine kinase inhibitor, as second-line therapy in patients with unresectable endometrial cancer. The primary end point was the objective response rate (ORR) as assessed by independent radiologic review (IRR). Secondary end points included median progression-free survival (PFS), overall survival (OS), and clinical benefit rate.

Is it necessary to use capsular endoscopy to diagnose celiac disease?

Aim: To clarify the indications for capsular endoscopy (CE) in patients with celiac disease.

Materials And Methods: The study included 10 patients with celiac disease (6 women, 4 men) aged 22 to 69 years. The median age was 42.

Crystal structure of recombinant phosphoribosylpyrophosphate synthetase 2 from Thermus thermophilus HB27 complexed with ADP and sulfate ions.

Phosphoribosylpyrophosphate synthetase (PRPPS) from the thermophilic bacterial strain Thermus thermophilus HB27 catalyzes the synthesis of phosphoribosylpyrophosphate from ribose 5-phosphate and ATP, and belongs to the class I PRPPSs. The three-dimensional structure of the recombinant enzyme was solved at 2.2 Å resolution using crystals grown in microgravity from protein solution containing ATP, magnesium and sulfate ions.

[Video capsule endoscopy is one more step towards improving the diagnosis of small intestinal diseases].

Aim: To estimate the value of video capsule endoscopy (VCE) in the diagnosis of small intestine (SI) diseases..

Subjects And Methods: A total of 134 patients, including 72 (53.

[Diffuse esophageal spasm: difficulties of diagnosis and treatment].

The article describes the diffuse esophageal spasm which is not amenable to conservative treatment.

[Anemia as the only symptom of esophageal hiatal hernia of the diaphragm].

The clinical case of chronic post-hemorrhagic iron deficiency anemia in patients with large hiatal hernia is represented in this article.

[Cardiovascular pathology associated with digestive system diseases].

With age, a person has "accumulation" of diseases. In patients of older age groups occurs simultaneously for at least 3-4 diseases. Assigning patients with ischemic heart disease (IHD), the physician takes into account the presence of concomitant diseases, especially diseases of the gastrointestinal tract, since the defeat of the stomach, liver, intestine may influence not only on the clinical course of heart disease, but also to change the pharmacokinetics of cardiac drugs.

[Liver and drug metabolism].

Liver metabolism aims to change the biological activity of drugs to make them water-soluble to be excreted with bile and urine. The degree of metabolism depends on fermentative capacity for each drag (P450 fermentative system is localized in microsomal fraction of hepatocyte). Metabolism ability also changes under the influence of other substances.

[Hypereosinophilic syndrome with the esophagus, stomach and small intestine pathology].

In this article the differential diagnostic line of blood hypereosinophilia is analyzed and the complicated clinical case of severe eosinophilic esophagogastroenteritis with recurrent oedema associated with protein loss is represented.

[Diagnostic criterion for anorexia nervosa].

Article presents a case of anorexia in 29 years old patient. Described the clinical symptoms of anorexia, the manifestations of the disease in patient; the premorbid characteristics of personality, the formation of which influences on relationships with parents.

[Pharmacokinetic and pharmacodynamic characteristics of antihypertensive drugs in the treatment of hypertensive patients with chronic diseases of the liver].

Aim: To determine optimal treatment of arterial hypertension (AH) in patients with hepatic cirrhosis (HC) basing on pharmacokinetic and pharmacodynamic characteristics of angiotensin-converting enzyme (ACE) inhibitors and beta-adrenoblockers (BAB).

Material And Methods: A total of 360 patients with AH of the second degree, steatosis and alcoholic HC of class A according to Child-Pue participated in the study. The control group consisted of 120 patients with peptic ulcer in remission and normal function of the liver.

[Pharmacokinetic and pharmacodynamic features of hypertensive drugs in treatment of patients with arterial hypertension associated with liver disease].

Research Objective: Being based on pharmacokinetic and pharmacodynamic property of inhibitor ACE and -adrenoblokers to optimise treatment of patients arterial hypertension (AH), a liver proceeding against chronic diseases.

Materials And Research Methods: In research it is included 360 patients with AH 2 degree in a combination with steatosis and the cirrhosis of liver of an alcoholic etiology of a class A by Chald-Pugh. In control group patients with stomach ulcer are included in stages of remission with normal function of a liver.

[Angiodysplasia and hemorrhages of the gastrointestinal tract as a particular manifestation of the connective tissue dysplasia].

The clinical case of hemorrhagic syndrome associated with alterations of gastrointestinal tract small vessels in the patient with connective tissue dysplasia, magnesium deficiency and with pathological addiction to alcohol is represented in this article.

[Combination therapy of arterial hypertension combined with liver pathology. The place of angiotensin converting enzyme inhibitors].

It is necessary to take into account presence of concomitant pathology while prescribing hypotensive therapy to patients with arterial hypertension (AH). Hydrophilic angiotensin converting enzyme inhibitors (ACEI) (lisinopril) which are not metabolized in the liver are theoretically safest in liver cirrhosis. We have examined and treated 180 patients with AH and assessed efficacy and tolerability of ACEI lisinopril and enalapril with consideration of their pharmacokinetic peculiarities in patients with various severity of involvement of the liver (steatosis or cirrhosis).

[Anorexia like severe extraintestinal diseases manifestations].

Patients with intra- and extrabowel diseases often have severe malnutrition as result of anorexia neuropsychica. The first investigators of this problem were W. Gull, Lasegue et al.