[Effect of stimulation of the reticular formation on the motivational and reinforcing effects of the self stimulation zones].

The influence was studied on the midbrain reticular formation (RF) on motivational and reinforcing effects of stimulation of the same selfstimulation zones (SS) of hypothalamic area. A current of gradually increasing intensity was used, by means of which three groups of functionally (behaviourally) specific reticular points were revealed: motivationaly neutral, positive and negative. The data obtained show that influences of RF on SS zones of hypothalamus differand depend on functional properties of various RF areas.

[Effect of excitation summation during interaction of self-stimulation zones].

A study was made on rats with electrodes implanted in the lateral preoptic hypothalamic area, of the interaction between distant foci of "positive" excitation in a situation when one of the foci (conditioning one) was set up by the animal itself by self-stimulation with a rhythmic current, while the other (testing) was imposed through stimulation of a different positive point with rhythmic and direct currents. Imposed stimulation of the distant positive zones by rhythmic current within a sufficiently wide range of intensities intensifies the self-stimulation in the conditioning focus. Polarization of the testing positive zones by a DC cathode produces a two-phase reaction of the conditioning points of self-stimulation: initial inhibition at the action of relatively weak DC intensities attended with its subsequent intensification when intensity of the polarizing current increases.

[Effect of amphotericin B on the enzyme system of Candida albicans].

The mechanism of amphotericin B action was studied with the aid of cytochemical methods providing determination of the activity of the 4 main enzymes characterizing the cell energetics, i. e. succinate dehydrogenase, lactate dehydrogenase, alcohol dehydrogenase and glucose-6-phosphate dehydrogenase inside the cell.

[Clinical aspects of lithium prevention of endogenous phasic-affective psychoses].

The report deals with the results of a long-term (up to 7 years) therapeuticoprophylactic use of lithium salts in 80 patients with manic-depressive psychosis and attack-like schizophrenia. It was possible to confirm the nosological predictiveness of this method in manic-depressive psychosis. The authors show some indications for the use of lithium in periodical schizophrenia with affective and affective-delusional attacks.

[Role of clinical and pharmacokinetic parameters in predicting the effectiveness of lithium salts in patients with affective psychoses].

Prophylactic treatment with common preparations of lithium carbonate and in its retarded form was given to 44 patients. The studies demonstrated an inverse correlation between the level of negative changes in the patients and the effect of treatment. The use of different methods of mathematical models demonstrated that in the group of patients who received lithium carbonate the most informative was the index of the half-life period and the period of half-elimination of lithium.

[Dynamics of changes in the concentration of luteinizing hormone in the pituitary and plasma and estrogens in blood of female rats during sexual maturation].

The dynamics of LH content in hypophysis and blood and oestrogen content in blood was studied in female rats from the 1st till the 42nd day of postnatal development. The two peaks of LH content in blood on the 18th and 22nd days correspond to the maximum accumulation of the hormone in hypophysis. The 3rd peak on the 41st day is somewhat behind the accumulation of the hormone in hypophysis (37th day).

[Effect of lithium on the energy metabolism of nervous tissue].

Lithium (0.5--4 mM) either significantly increase, either completely normalizers the intensity of the oxidative and energy metabolism of the brain mitochondria, decreased by the influence of the blood serum of patients with manic-depressive psychosis and attack like schizophrenia. At the same time lithium gives an insignificant increase in the intensity of processes of phosphorilation in cases of an action of the blood serum of patients with a continuous development of schizophrenia.

[Changes in the concentration of estradiol in the peripheral blood of immature female rats following intrahypothalamic administration of a factor liberating luteinizing hormone].

Administration of a synthetic luteinizing hormone-releasing factor (LH-RF) into the area of the medial eminence and the third ventricle of the sexually immature female rats, aged 20-22 days, caused a distinct increase in the estradiol concentration in the peripheral blood of the majority of these animals. Administration of physiological solution produced a reaction (much weaker) only in a small percentage of the animals. There was no increase in estradiol level when LH-RF got into the other areas of the hypothalamus.