Publications by authors named "Mikhail Uimin"
Novel magnetic nanocomposite materials based on FeO nanoparticles coated with iron and silica glycerolates (MNP@Fe(III)Glyc and MNP@Fe(III)/SiGlyc) were obtained. The synthesized nanocomposites were characterized using TEM, XRD, TGA, VMS, Mössbauer and IR spectroscopy. The amount of iron and silica glycerolates in the nanocomposites was calculated from the Mössbauer spectroscopy, ICP AES and C,H-elemental analysis.
View Article and Find Full Text PDFA series of new composite materials based on FeO magnetic nanoparticles coated with SiO (or aminated SiO) were synthesized. It has been shown that the use of -(phosphonomethyl)iminodiacetic acid (PMIDA) to stabilize nanoparticles before silanization ensures the increased content of a SiO phase in the FeO@SiO nanocomposites (NCs) in comparison with materials obtained under similar conditions, but without PMIDA. It has been demonstrated for the first time that the presence of PMIDA on the surface of NCs increases the level of Dox loading due to specific binding, while surface modification with 3-aminopropylsilane, on the contrary, significantly reduces the sorption capacity of materials.
View Article and Find Full Text PDFPeptide ligands on the PEGylated nanoparticle surface and human serum composition are key factors for the interaction between immune cells and nanoparticles.
Colloids Surf B Biointerfaces
January 2023
Article Synopsis
- The surface architecture of nanoparticles, influenced by ligand modifications and protein interactions in biofluids, is essential for their cellular interactions in living organisms.
- In this study, we examined how immune cells interact with magnetic nanoparticles modified with polyethylene glycol (PEG) and peptide ligands, discovering that pHLIP modification improved their uptake by immune cells compared to cycloRGD.
- Although we didn't find notable differences in protein corona composition between the modified and unmodified nanoparticles, variations in nanoparticle uptake were observed among different individuals, highlighting the need to consider personal differences in serum during nanotherapy testing.
Article Synopsis
- Novel nanocomposite materials were created using FeO magnetic nanoparticles coated with silica and modified for enhanced doxorubicin (Dox) loading.
- * The study tested how efficiently Dox can be released from these nanoparticles when exposed to an alternating magnetic field (AMF) in both acidic and neutral conditions.
- * Results showed that the nanoparticles were highly toxic to tumor cells, and the use of AMF improved the drug release, increasing the cytotoxic impact.
The magnetic and microwave properties of nanocomposites containing iron particles encapsulated in a carbon shell (Fe@C), as well as carbon nanotubes (CNT), have been experimentally studied. The examination of magnetic properties of composites shows that the materials under study contain a ferromagnetic component. The availability of ferromagnetic ordering for the dielectric matrix-based nanocomposite sample with Fe@C particles has been confirmed by the measurement results of the transmission and the reflection coefficients of the microwaves, since the ferromagnetic resonance has been observed.
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- Researchers created innovative organosilicon MNPs modified with pHLIP and PEG, showing enhanced specificity and low cytotoxicity in vitro, particularly at acidic pH levels.
- The study revealed that these pHLIP-modified MNPs accumulated significantly more in tumors compared to standard PEGylated MNPs in mouse models, indicating their potential for better cancer imaging.
L-Lysine-modified FeO nanoparticles for magnetic cell labeling.
Colloids Surf B Biointerfaces
June 2020
The efficiency of magnetic labeling with L-Lys-modified FeO magnetic nanoparticles (MNPs) and the stability of magnetization of rat adipose-derived mesenchymal stem cells, lineage-negative (Lin(-)) hematopoietic progenitor cells from mouse bone marrow and human leukemia K562 cells were studied. For this purpose, covalent modification of MNPs with 3-aminopropylsilane and N-di-Fmoc-L-lysine followed by removal of N-protecting groups was carried out. Since the degree of hydroxylation of the surface of the starting nanoparticles plays a crucial role in the silanization reaction and the possibility of obtaining stable colloidal solutions.
View Article and Find Full Text PDFConjugation of carbon coated-iron nanoparticles with biomolecules for NMR-based assay.
Colloids Surf B Biointerfaces
April 2019
In this work, we developed and optimized conjugates of carbon-coated iron nanoparticles (Fe@C) with streptavidin and monoclonal antibodies. The conjugation procedure included two stages. First, amino groups were grafted onto the carbon shell to facilitate noncovalent sorption of bovine serum albumin (BSA).
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- * It was found that the best modification conditions involved a reaction at 40 °C with an equimolar amount of PMIDA for 3.5 hours, resulting in good colloidal stability and high magnetic properties of the MNPs.
- * The PMIDA-modified MNPs showed superior performance with relaxivity values of 341 and 102 mmol s, and were successfully tested as a T1 contrast agent for liver imaging in vivo, indicating their potential medical application.