A pilot study assessing adherence to auto-bilevel following a poor initial encounter with CPAP.

Study Objectives: We hypothesized that early intervention with an auto bilevel device would improve treatment adherence compared to CPAP among OSA patients with a poor initial experience with lab-based CPAP titration.

Methods: Patients with a poor initial CPAP experience were recruited for this parallel group, randomized, double-blind, controlled pilot study. After an in-lab titration, patients were randomized with either an auto-bilevel device or CPAP.

Uterine angioleiomyoma complicated by consumptive coagulopathy.

► We present a rare case of consumptive coagulopathy secondary to a large degenerated uterine angioleiomyoma. ► Pathological examination showed features of angioleiomyoma, which are rarely found in the uterus. ► After removal of the neoplasm, the patient's consumptive coagulopathy, along with her vaginal bleeding, subsequently resolved.

Influence of the Circadian System on Disease Severity.

The severity of many diseases varies across the day and night. For example, adverse cardiovascular incidents peak in the morning, asthma is often worse at night and temporal lobe epileptic seizures are most prevalent in the afternoon. These patterns may be due to the day/night rhythm in environment and behavior, and/or endogenous circadian rhythms in physiology.